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Target Report Card

Target Name and Classification

Target ID CHEMBL1075113
Preferred Name Toll-like receptor 3
Synonyms CD_antigen=CD283 | TLR3 | Toll-like receptor 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > toll-like and il-1 receptors

Target Components

Component Description Relationship Accession
Toll-like receptor 3 SINGLE PROTEIN O15455

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2107862 RINTATOLIMOD Toll-like receptor 3 agonist 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164342
Ensembl ENSG00000164342
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005622 (intracellular)
GO:0005737 (cytoplasm)
GO:0005765 (lysosomal membrane)
GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0010008 (endosome membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0036020 (endolysosome membrane)
GO Molecular Function GO:0003723 (RNA binding)
GO:0003725 (double-stranded RNA binding)
GO:0004888 (transmembrane signaling receptor activity)
GO:0005515 (protein binding)
GO:0038023 (signaling receptor activity)
GO:0042802 (identical protein binding)
GO Biological Process GO:0001774 (microglial cell activation)
GO:0001819 (positive regulation of cytokine production)
GO:0002224 (toll-like receptor signaling pathway)
GO:0002376 (immune system process)
GO:0002730 (regulation of dendritic cell cytokine production)
GO:0002756 (MyD88-independent toll-like receptor signaling pathway)
GO:0006952 (defense response)
GO:0006954 (inflammatory response)
GO:0006972 (hyperosmotic response)
GO:0007165 (signal transduction)
GO:0007249 (I-kappaB kinase/NF-kappaB signaling)
GO:0007250 (activation of NF-kappaB-inducing kinase activity)
GO:0007252 (I-kappaB phosphorylation)
GO:0008584 (male gonad development)
GO:0009597 (detection of virus)
GO:0009615 (response to virus)
GO:0010628 (positive regulation of gene expression)
GO:0032481 (positive regulation of type I interferon production)
GO:0032722 (positive regulation of chemokine production)
GO:0032728 (positive regulation of interferon-beta production)
GO:0032735 (positive regulation of interleukin-12 production)
GO:0032755 (positive regulation of interleukin-6 production)
GO:0032757 (positive regulation of interleukin-8 production)
GO:0032760 (positive regulation of tumor necrosis factor production)
GO:0034123 (positive regulation of toll-like receptor signaling pathway)
GO:0034128 (negative regulation of MyD88-independent toll-like receptor signaling pathway)
GO:0034138 (toll-like receptor 3 signaling pathway)
GO:0034346 (positive regulation of type III interferon production)
GO:0035458 (cellular response to interferon-beta)
GO:0035666 (TRIF-dependent toll-like receptor signaling pathway)
GO:0035690 (cellular response to drug)
GO:0042742 (defense response to bacterium)
GO:0043065 (positive regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043330 (response to exogenous dsRNA)
GO:0043331 (response to dsRNA)
GO:0045078 (positive regulation of interferon-gamma biosynthetic process)
GO:0045080 (positive regulation of chemokine biosynthetic process)
GO:0045087 (innate immune response)
GO:0045356 (positive regulation of interferon-alpha biosynthetic process)
GO:0045359 (positive regulation of interferon-beta biosynthetic process)
GO:0045671 (negative regulation of osteoclast differentiation)
GO:0045766 (positive regulation of angiogenesis)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046330 (positive regulation of JNK cascade)
GO:0050729 (positive regulation of inflammatory response)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051607 (defense response to virus)
GO:0070266 (necroptotic process)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071346 (cellular response to interferon-gamma)
GO:0071359 (cellular response to dsRNA)
GO:0071360 (cellular response to exogenous dsRNA)
GO:0097190 (apoptotic signaling pathway)
GO:0097191 (extrinsic apoptotic signaling pathway)
GO:0097527 (necroptotic signaling pathway)
GO:1901224 (positive regulation of NIK/NF-kappaB signaling)
Wikipedia TLR_3

Target Cross References - Protein

canSAR O15455
CGD Herpes simplex encephalitis, susceptibility to, 2
Human Protein Atlas ENSG00000164342
IntAct O15455
Open Targets ENSG00000164342
PharmGKB PA36551
Reactome R-HSA-1679131 (Trafficking and processing of endosomal TLR.)
R-HSA-168164 (Toll Like Receptor 3 (TLR3) Cascade.)
R-HSA-168927 (TICAM1, RIP1-mediated IKK complex recruitment.)
R-HSA-1810476 (RIP-mediated NFkB activation via ZBP1.)
R-HSA-5602410 (TLR3 deficiency - HSE.)
R-HSA-5602415 (UNC93B1 deficiency - HSE.)
R-HSA-5602566 (TICAM1 deficiency - HSE.)
R-HSA-5602571 (TRAF3 deficiency - HSE.)
R-HSA-9013957 (TLR3-mediated TICAM1-dependent programmed cell death.)
R-HSA-9013973 (TICAM1-dependent activation of IRF3/IRF7.)
R-HSA-9014325 (TICAM1,TRAF6-dependent induction of TAK1 complex.)
R-HSA-937072 (TRAF6-mediated induction of TAK1 complex within TLR4 complex.)
R-HSA-975163 (IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.)
UniProt B2RAI7 B7Z7K0 E6Y0F0 E6Y0F1 E9PGH4 O15455 Q4VAL2 Q504W0

Target Cross References - Domain

InterPro IPR000157 (TIR_dom.)
IPR000483 (Cys-rich_flank_reg_C.)
IPR001611 (Leu-rich_rpt.)
IPR003591 (Leu-rich_rpt_typical-subtyp.)
IPR027173 (TLR3.)
IPR032675 (LRR_dom_sf.)
IPR035897 (Toll_tir_struct_dom_sf.)
Pfam PF01582 (TIR)
PF13516 (LRR_6)
PF13855 (LRR_8)

Target Cross References - Structure