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Target Report Card

Target Name and Classification

Target ID CHEMBL1075102
Target Type SINGLE PROTEIN
Preferred Name Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha
Synonyms PI3K-C2-alpha | PIK3C2A | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha | Phosphoinositide 3-kinase-C2-alpha | PtdIns-3-kinase C2 subunit alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha SINGLE PROTEIN O00443

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000011405
Ensembl ENSG00000011405
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005942 (phosphatidylinositol 3-kinase complex)
GO:0016020 (membrane)
GO:0030136 (clathrin-coated vesicle)
GO:0031410 (cytoplasmic vesicle)
GO:0031982 (vesicle)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016303 (1-phosphatidylinositol-3-kinase activity)
GO:0016740 (transferase activity)
GO:0035004 (phosphatidylinositol 3-kinase activity)
GO:0035005 (1-phosphatidylinositol-4-phosphate 3-kinase activity)
GO:0035091 (phosphatidylinositol binding)
GO Biological Process GO:0006661 (phosphatidylinositol biosynthetic process)
GO:0006887 (exocytosis)
GO:0006897 (endocytosis)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0008286 (insulin receptor signaling pathway)
GO:0014829 (vascular smooth muscle contraction)
GO:0016310 (phosphorylation)
GO:0036092 (phosphatidylinositol-3-phosphate biosynthetic process)
GO:0046854 (phosphatidylinositol phosphorylation)
GO:0048008 (platelet-derived growth factor receptor signaling pathway)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0048268 (clathrin coat assembly)
Wikipedia PIK3C2A

Target Cross References - Protein

canSAR O00443
Human Protein Atlas ENSG00000011405
IntAct O00443
Guide to Pharmacology 2150
Open Targets ENSG00000011405
PharmGKB PA33304
Pharos O00443 (Tchem)
Reactome R-HSA-1660499 (Synthesis of PIPs at the plasma membrane.)
R-HSA-1660514 (Synthesis of PIPs at the Golgi membrane.)
R-HSA-1660516 (Synthesis of PIPs at the early endosome membrane.)
R-HSA-1660517 (Synthesis of PIPs at the late endosome membrane.)
R-HSA-432722 (Golgi Associated Vesicle Biogenesis.)
R-HSA-8856828 (Clathrin-mediated endocytosis.)
UniProt B0LPH2 B4E2G4 O00443 Q14CQ9

Target Cross References - Domain

InterPro IPR000008 (C2_dom.)
IPR000341 (PI3K_Ras-bd_dom.)
IPR000403 (PI3/4_kinase_cat_dom.)
IPR001263 (PInositide-3_kin_accessory_dom.)
IPR001683 (Phox.)
IPR002420 (PI3K_C2_dom.)
IPR011009 (Kinase-like_dom.)
IPR015433 (PI_Kinase.)
IPR016024 (ARM-type_fold.)
IPR018936 (PI3/4_kinase_CS.)
IPR029071 (Ubiquitin-rel_dom.)
Pfam PF00168 (C2)
PF00454 (PI3_PI4_kinase)
PF00613 (PI3Ka)
PF00787 (PX)
PF00792 (PI3K_C2)
PF00794 (PI3K_rbd)

Target Cross References - Structure

PDBe 2AR5 2IWL 2REA 2RED
CREDO 2AR5 2IWL 2REA 2RED
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