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Target Report Card

Target Name and Classification

Target ID CHEMBL1075094
Preferred Name Nuclear factor erythroid 2-related factor 2
Synonyms HEBP1 | NF-E2-related factor 2 | NFE2-related factor 2 | NFE2L2 | NRF2 | Nuclear factor erythroid 2-related factor 2 | Nuclear factor, erythroid derived 2, like 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Nuclear factor erythroid 2-related factor 2 SINGLE PROTEIN Q16236

Target Relations

ChEMBL ID Pref Name Target Type

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000116044
Ensembl ENSG00000116044
GO Cellular Component GO:0000785 (chromatin)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0032993 (protein-DNA complex)
GO Molecular Function GO:0000976 (transcription regulatory region sequence-specific DNA binding)
GO:0000980 (RNA polymerase II distal enhancer sequence-specific DNA binding)
GO:0001102 (RNA polymerase II activating transcription factor binding)
GO:0001205 (transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding)
GO:0001221 (transcription cofactor binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0019904 (protein domain specific binding)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006954 (inflammatory response)
GO:0010499 (proteasomal ubiquitin-independent protein catabolic process)
GO:0010628 (positive regulation of gene expression)
GO:0016567 (protein ubiquitination)
GO:0030194 (positive regulation of blood coagulation)
GO:0030968 (endoplasmic reticulum unfolded protein response)
GO:0034599 (cellular response to oxidative stress)
GO:0034976 (response to endoplasmic reticulum stress)
GO:0035690 (cellular response to drug)
GO:0036003 (positive regulation of transcription from RNA polymerase II promoter in response to stress)
GO:0036091 (positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)
GO:0036499 (PERK-mediated unfolded protein response)
GO:0042149 (cellular response to glucose starvation)
GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process)
GO:0045454 (cell redox homeostasis)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0045995 (regulation of embryonic development)
GO:0046326 (positive regulation of glucose import)
GO:0060548 (negative regulation of cell death)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0071356 (cellular response to tumor necrosis factor)
GO:0071498 (cellular response to fluid shear stress)
GO:0071499 (cellular response to laminar fluid shear stress)
GO:1902037 (negative regulation of hematopoietic stem cell differentiation)
GO:1902176 (negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)
GO:1903071 (positive regulation of ER-associated ubiquitin-dependent protein catabolic process)
GO:1903206 (negative regulation of hydrogen peroxide-induced cell death)
GO:1903788 (positive regulation of glutathione biosynthetic process)
GO:2000121 (regulation of removal of superoxide radicals)
GO:2000352 (negative regulation of endothelial cell apoptotic process)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)
Wikipedia NFE2L2

Target Cross References - Protein

canSAR Q16236
Human Protein Atlas ENSG00000116044
IntAct Q16236
Open Targets ENSG00000116044
PharmGKB PA31588
UniProt B2RBU2 B4E338 E9PGJ7 Q16236 Q53RW6 Q59HH2 Q96F71

Target Cross References - Domain

InterPro IPR004826 (bZIP_Maf.)
IPR004827 (bZIP.)
IPR008917 (TF_DNA-bd.)
IPR029845 (Nrf2.)
Pfam PF03131 (bZIP_Maf)

Target Cross References - Structure