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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL925
CHEMBL925
Compound Name TYROSINE
ChEMBL Synonyms TYROSINE
Max Phase 4 (Approved)
Trade Names
Molecular Formula C9H11NO3

Additional synonyms for CHEMBL925 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)O
Standard InChI InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11 ...
Download InChI
Standard InChI Key OUYCCCASQSFEME-QMMMGPOBSA-N

Sources

  • Orange Book
  • PubChem BioAssays
  • Scientific Literature
  • TP-search Transporter Database
  • USP Dictionary of USAN and International Drug Names

Alternate Forms of Compound in ChEMBL


CHEMBL925

Molecule Features

CHEMBL925 compound icon
Drug Type:Synthetic Small Molecule Rule of Five:Y First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:Y Parenteral:N Topical:N Black Box:N Availability Type:Discontinued

Clinical Data

ClinicalTrials.gov TYROSINE
The Cochrane Collaboration TYROSINE

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Target Predictions

The two tables below display ChEMBL single-protein targets which are predicted to interact with CHEMBL925. A 1uM and 10 uM cut-off have been applied to ChEMBL bioactivity data used to generate the respective models and the yellow coloured rows correspond to genuine predictions, i.e. targets not included in the original training set for this compound.


1uM


ChEMBL_ID Target Name Organism Score
CHEMBL270 Mu opioid receptor Rattus norvegicus 1.000
CHEMBL2009 Glutamate receptor ionotropic, AMPA 1 Homo sapiens 1.000
CHEMBL269 Delta opioid receptor Rattus norvegicus 1.000
CHEMBL3753 Glutamate receptor ionotropic, AMPA 1 Rattus norvegicus 1.000
CHEMBL4354 Mu opioid receptor Cavia porcellus 1.000
CHEMBL5689 Tryptophan 5-hydroxylase 1 Homo sapiens 1.000
CHEMBL3222 Delta opioid receptor Mus musculus 1.000
CHEMBL3768 Neprilysin Oryctolagus cuniculus 1.000
CHEMBL2590 Aminopeptidase N Sus scrofa 0.999
CHEMBL4581 Kinesin-like protein 1 Homo sapiens 0.997
CHEMBL236 Delta opioid receptor Homo sapiens 0.993
CHEMBL278 Integrin alpha-4 Homo sapiens 0.949
CHEMBL2919 Glutamate receptor ionotropic kainate 1 Rattus norvegicus 0.861
CHEMBL4074 Angiotensin-converting enzyme Oryctolagus cuniculus 0.841
CHEMBL4027 Neurokinin 1 receptor Rattus norvegicus 0.822
CHEMBL3369 Neprilysin Rattus norvegicus 0.811
CHEMBL1808 Angiotensin-converting enzyme Homo sapiens 0.750
CHEMBL233 Mu opioid receptor Homo sapiens 0.728
CHEMBL2625 Angiotensin-converting enzyme Rattus norvegicus 0.723
CHEMBL1293237 Bloom syndrome protein Homo sapiens 0.705



10uM


ChEMBL_ID Target Name Organism Score
CHEMBL270 Mu opioid receptor Rattus norvegicus 1.000
CHEMBL2009 Glutamate receptor ionotropic, AMPA 1 Homo sapiens 1.000
CHEMBL269 Delta opioid receptor Rattus norvegicus 1.000
CHEMBL3753 Glutamate receptor ionotropic, AMPA 1 Rattus norvegicus 1.000
CHEMBL4354 Mu opioid receptor Cavia porcellus 1.000
CHEMBL3222 Delta opioid receptor Mus musculus 1.000
CHEMBL2693 Cystinyl aminopeptidase Homo sapiens 1.000
CHEMBL5689 Tryptophan 5-hydroxylase 1 Homo sapiens 1.000
CHEMBL1907 Aminopeptidase N Homo sapiens 1.000
CHEMBL2590 Aminopeptidase N Sus scrofa 1.000
CHEMBL2919 Glutamate receptor ionotropic kainate 1 Rattus norvegicus 1.000
CHEMBL3768 Neprilysin Oryctolagus cuniculus 0.999
CHEMBL4581 Kinesin-like protein 1 Homo sapiens 0.999
CHEMBL236 Delta opioid receptor Homo sapiens 0.989
CHEMBL1808 Angiotensin-converting enzyme Homo sapiens 0.984
CHEMBL4074 Angiotensin-converting enzyme Oryctolagus cuniculus 0.973
CHEMBL278 Integrin alpha-4 Homo sapiens 0.941
CHEMBL4027 Neurokinin 1 receptor Rattus norvegicus 0.884
CHEMBL2625 Angiotensin-converting enzyme Rattus norvegicus 0.830
CHEMBL3614 Kappa opioid receptor Rattus norvegicus 0.786

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
181.2 181.0739 -1.85 3 83.55 ZWITTERION


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
4 3 0 4 4 0


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
2.25 9.09 -.42 -2.93 1 13 0.51

Structural Alerts

There are 1 structural alerts for CHEMBL925. To view alerts please click here.

Compound Cross References

ChemSpider ChemSpider:OUYCCCASQSFEME-QMMMGPOBSA-N
DailyMed tyrosine
PubChem SID: 144205147 SID: 170466853 SID: 29215265
Wikipedia Tyrosine

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL925



ACToR 140-43-2 25619-78-7
BindingDB 18129
Brenda 709 30315 618 109 20761 45800 47528 415
ChEBI 58315 17895
DrugBank DB00135
DrugCentral 2786
eMolecules 26757083 514474
EPA CompTox Dashboard DTXSID1023730
FDA SRS 42HK56048U
Guide to Pharmacology 4791
Human Metabolome Database HMDB0000158
IBM Patent System 7CDEE543702AEACC282560B299A3AEF5
KEGG Ligand C00082
Mcule MCULE-2932088896 MCULE-8059108702
Metabolights MTBLC17895 MTBLC58315
Nikkaji J9.173A
PDBe TYR
PharmGKB PA451822
PubChem 6942100 6057
PubChem: Thomson Pharma 15147336 15195185
Recon tyr_L
SureChEMBL SCHEMBL1581
ZINC ZINC000000266964

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/OUYCCCASQSFEME-QMMMGPOBSA-N spacer
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