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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL607400
CHEMBL607400
Compound Name BRIVARACETAM
ChEMBL Synonyms UCB 34714 | BRIVARACETAM
Max Phase 4 (Approved)
Trade Names
Molecular Formula C11H20N2O2

Additional synonyms for CHEMBL607400 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES CCC[C@H]1CN([C@@H](CC)C(=O)N)C(=O)C1
Standard InChI InChI=1S/C11H20N2O2/c1-3-5-8-6-10(14)13(7-8)9(4-2)11(12)15/h ...
Download InChI
Standard InChI Key MSYKRHVOOPPJKU-BDAKNGLRSA-N

Sources

  • British National Formulary
  • Orange Book
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Alternate Forms of Compound in ChEMBL


CHEMBL607400

Molecule Features

CHEMBL607400 compound icon
Drug Type:Synthetic Small Molecule Rule of Five:Y First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:Y Parenteral:Y Topical:N Black Box:N Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Synaptic vesicle glycoprotein 2A modulator Synaptic vesicle glycoprotein 2A FDA PubMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
EPILEPSYD004827EFO:0000474EPILEPSY4ATC
FDA
ClinicalTrials
SEIZURESD012640HP:0001250SEIZURES2ClinicalTrials
HERPES ZOSTER OTICUSD016697EFO:0007281GENICULATE HERPES ZOSTER2ClinicalTrials

Clinical Data

ClinicalTrials.gov BRIVARACETAM
The Cochrane Collaboration BRIVARACETAM

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Target Predictions

The two tables below display ChEMBL single-protein targets which are predicted to interact with CHEMBL607400. A 1uM and 10 uM cut-off have been applied to ChEMBL bioactivity data used to generate the respective models and the yellow coloured rows correspond to genuine predictions, i.e. targets not included in the original training set for this compound.


1uM


ChEMBL_ID Target Name Organism Score
CHEMBL204 Thrombin Homo sapiens 0.363

10uM


ChEMBL_ID Target Name Organism Score
CHEMBL204 Thrombin Homo sapiens 0.294

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
212.3 212.1525 0.93 5 63.4 NEUTRAL


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
2 1 0 4 2 0


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
- - .67 .67 0 15 0.74

Structural Alerts

There are no structural alerts for CHEMBL607400

Compound Cross References

ATC N - NERVOUS SYSTEM
N03 - ANTIEPILEPTICS
N03A - ANTIEPILEPTICS
N03AX - Other antiepileptics
N03AX23 - brivaracetam

ChemSpider ChemSpider:MSYKRHVOOPPJKU-BDAKNGLRSA-N
DailyMed brivaracetam
Wikipedia Brivaracetam

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL607400



BindingDB 50422531
ChEBI 133013
DrugBank DB05541
DrugCentral 5068
FDA SRS U863JGG2IA
Guide to Pharmacology 9041
IBM Patent System 041EFBCC3D02E3390EF1CA587099F11D
Nikkaji J2.411.659J
PharmGKB PA166153491
PubChem 9837243
PubChem: Drugs of the Future 22395457
PubChem: Thomson Pharma 14797750
SureChEMBL SCHEMBL122081
ZINC ZINC000003979899

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/MSYKRHVOOPPJKU-BDAKNGLRSA-N spacer
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