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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL451887
CHEMBL451887
Compound Name CARFILZOMIB
ChEMBL Synonyms KYPROLIS | PR-171 | CARFILZOMIB
Max Phase 4 (Approved)
Trade Names KYPROLIS
Molecular Formula C40H57N5O7

Additional synonyms for CHEMBL451887 found using NCI Chemical Identifier Resolver

Sources

  • Manually Added Drugs
  • Orange Book
  • PubChem BioAssays
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Molecule Features

CHEMBL451887 compound icon
Drug Type:Oligopeptide Rule of Five:N First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:N Parenteral:Y Topical:N Black Box:N Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
26S proteosome inhibitor 26S proteosome FDA PubMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
CARCINOMA, RENAL CELLD002292EFO:0002890RENAL CARCINOMA2ClinicalTrials
GRAFT VS HOST DISEASED006086EFO:0004599ACUTE GRAFT VS. HOST DISEASE2ClinicalTrials
LEUKEMIAD007938EFO:0000565LEUKEMIA1ClinicalTrials
LYMPHOMAD008223EFO:0000574LYMPHOMA2ClinicalTrials
NEOPLASMSD009369EFO:0000616NEOPLASM4ATC
NEOPLASMSD009369EFO:0000311CANCER4ClinicalTrials
MULTIPLE MYELOMAD009101EFO:0001378MULTIPLE MYELOMA4DailyMed
ClinicalTrials
PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMAD054198EFO:0000220ACUTE LYMPHOBLASTIC LEUKEMIA1ClinicalTrials

Clinical Data

ClinicalTrials.gov CARFILZOMIB
The Cochrane Collaboration CARFILZOMIB

HELM Notation

CHEMBL451887 HELM Notation
PEPTIDE1{[X644].[Hph].L.F.[X105]}$$$$

The ChEMBL HELM monomer library is available to download here.

For more details about HELM Notation, please visit the HELM Homepage.

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Compound Cross References

ATC L - ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 - ANTINEOPLASTIC AGENTS
L01X - OTHER ANTINEOPLASTIC AGENTS
L01XX - Other antineoplastic agents
L01XX45 - carfilzomib

ChemSpider ChemSpider:BLMPQMFVWMYDKT-NZTKNTHTSA-N
DailyMed carfilzomib
PubChem SID: 124955654 SID: 144206630 SID: 170466878

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL451887



ACToR 868540-17-4
BindingDB 50277889
Brenda 83670
ChEBI 65347
DrugBank DB08889
DrugCentral 4483
EPA CompTox Dashboard DTXSID4048690
FDA SRS 72X6E3J5AR
Guide to Pharmacology 7420
IBM Patent System D8BECA537E502903BDADF9675DEAE9F1
MolPort MolPort-027-950-907
Nikkaji J2.711.864J
PharmGKB PA166165203
PubChem 11556711
PubChem: Drugs of the Future 92309411
PubChem: Thomson Pharma 16812122 16658822
Selleck carfilzomib-pr-171
SureChEMBL SCHEMBL85165
ZINC ZINC000049841054

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/BLMPQMFVWMYDKT-NZTKNTHTSA-N spacer
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