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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL43452
CHEMBL43452
Compound Name POMALIDOMIDE
ChEMBL Synonyms IMID-3 | CC-4047 | Pomalidomide
Max Phase 4 (Approved)
Trade Names
Molecular Formula C13H11N3O4

Additional synonyms for CHEMBL43452 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
Standard InChI InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4- ...
Download InChI
Standard InChI Key UVSMNLNDYGZFPF-UHFFFAOYSA-N

Molecule Features

CHEMBL43452 compound icon
Drug Type:Synthetic Small Molecule Rule of Five:Y First In Class:N Chirality:Racemic Mixture Prodrug:N Oral:Y Parenteral:N Topical:N Black Box:Y Availability Type:Prescription-only

Clinical Trials for Compound

Number of clinical trials registered at clinicaltrials.gov

Alternate Forms of Compound in ChEMBL


CHEMBL43452

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Target Predictions

The two tables below display ChEMBL single-protein targets which are predicted to interact with CHEMBL43452. A 1uM and 10 uM cut-off have been applied to ChEMBL bioactivity data used to generate the respective models and the yellow coloured rows correspond to genuine predictions, i.e. targets not included in the original training set for this compound.


1uM


ChEMBL_ID Target Name Organism Score
CHEMBL217 Dopamine D2 receptor Homo sapiens 0.769
CHEMBL339 Dopamine D2 receptor Rattus norvegicus 0.251

10uM


ChEMBL_ID Target Name Organism Score
CHEMBL217 Dopamine D2 receptor Homo sapiens 0.746
CHEMBL339 Dopamine D2 receptor Rattus norvegicus 0.270

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Ro5 Violations #Rotatable Bonds Ro3 Med Chem Friendly Molecular Species
273.2 273.075 -0.65 0 1 No Yes NEUTRAL


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms Num Alerts QED Weighted
10.75 - -.71 -.71 1 20 2 0.52

Compound Cross References

ATC L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L04 IMMUNOSUPPRESSANTS
L04A IMMUNOSUPPRESSANTS
L04AX Other immunosuppressants
L04AX06 pomalidomide

ChemSpider ChemSpider:UVSMNLNDYGZFPF-UHFFFAOYSA-N
DailyMed pomalidomide
Wikipedia Pomalidomide

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL43452



DrugBank DB08910
PubChem: Drugs of the Future 50086901
ChEBI 72690
eMolecules 32278076
IBM Patent System AC3A7326240A5FEE40CEF82B288339E4
Patent WO1998003502A1 EP0925294A1 US5635517
Selleck Pomalidomide(CC-4047)
PubChem: Thomson Pharma 14848461
PubChem 134780

UniChem REST Service Call: https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/UVSMNLNDYGZFPF-UHFFFAOYSA-N spacer
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