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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL429876
CHEMBL429876
Compound Name CILENGITIDE
ChEMBL Synonyms CILENGITIDE | EMD-121974 | EMD-12192
Max Phase 3
Trade Names
Molecular Formula C27H40N8O7

Additional synonyms for CHEMBL429876 found using NCI Chemical Identifier Resolver

Sources

  • Clinical Candidates
  • Gene Expression Atlas Compounds
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names

Molecule Features

CHEMBL429876 compound icon
Drug Type:Oligopeptide Rule of Five:N First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:Unclassified Parenteral:Unclassified Topical:Unclassified Black Box:Unclassified Availability Type:Unclassified

Mechanism of Action

Mechanism of Action ChEMBL Target References
Integrin alpha-V/beta-3 antagonist Integrin alpha-V/beta-3 PubMed PubMed
Integrin alpha-V/beta-5 antagonist Integrin alpha-V/beta-5 PubMed PubMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
PROSTATIC NEOPLASMSD011471EFO:0001663PROSTATE CARCINOMA2ClinicalTrials
MELANOMAD008545EFO:0000756MELANOMA2ClinicalTrials
GLIOBLASTOMAD005909EFO:0000519GLIOBLASTOMA MULTIFORME2ClinicalTrials
GLIOSARCOMAD018316EFO:1001465GLIOSARCOMA2ClinicalTrials
NEOPLASMSD009369EFO:0000616NEOPLASM1ClinicalTrials
SARCOMAD012509EFO:0000691SARCOMA1ClinicalTrials

Clinical Data

ClinicalTrials.gov CILENGITIDE
The Cochrane Collaboration CILENGITIDE

HELM Notation

CHEMBL429876 HELM Notation
PEPTIDE1{[meV].R.G.D.[dF]}$PEPTIDE1,PEPTIDE1,5:R2-1:R1$$$

The ChEMBL HELM monomer library is available to download here.

For more details about HELM Notation, please visit the HELM Homepage.

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Compound Cross References

ChemSpider ChemSpider:AMLYAMJWYAIXIA-VWNVYAMZSA-N
Wikipedia Cilengitide

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL429876



ACToR 188968-51-6
BindingDB 50235980
DrugBank DB11890
EPA CompTox Dashboard DTXSID9044035
FDA SRS 4EDF46E4GI
Guide to Pharmacology 6597
IBM Patent System 1301776DB04C4F521CE3A114605696A3
MolPort MolPort-035-395-751
Nikkaji J1.358.368D
PubChem 176873
PubChem: Drugs of the Future 12015138
PubChem: Thomson Pharma 14764661 14886950
Selleck cilengitide-emd-121974-nsc-707544
SureChEMBL SCHEMBL34082
ZINC ZINC000003952216

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/AMLYAMJWYAIXIA-VWNVYAMZSA-N spacer
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