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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL427216
CHEMBL427216
Compound Name GLICLAZIDE
ChEMBL Synonyms DIAMICRON MR | DIAGLYK | DACADIS MR | VAMJU | BILXONA | GLIMIL | EDICIL | DIAMICRON | VITILE XL | GLICLAZIDE | NAZDOL MR | ZICRON | SE 1702 | ZICLASEG | ZICRON PR
Max Phase 4 (Approved)
Trade Names ZICLASEG | DACADIS MR | DIAGLYK | ZICRON PR | BILXONA | VAMJU | VITILE XL | DIAMICRON | EDICIL | GLIMIL | NAZDOL MR | DIAMICRON MR | ZICRON
Molecular Formula C15H21N3O3S

Additional synonyms for CHEMBL427216 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)NN2CC3CCCC3C2
Standard InChI InChI=1S/C15H21N3O3S/c1-11-5-7-14(8-6-11)22(20,21)17-15(19)1 ...
Download InChI
Standard InChI Key BOVGTQGAOIONJV-UHFFFAOYSA-N

Sources

  • British National Formulary
  • DrugMatrix
  • PubChem BioAssays
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Alternate Forms of Compound in ChEMBL


CHEMBL427216

Molecule Features

CHEMBL427216 compound icon
Drug Type:Synthetic Small Molecule Rule of Five:Y First In Class:N Chirality:Racemic Mixture Prodrug:N Oral:N Parenteral:N Topical:N Black Box:N Availability Type:Unknown

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
EpilepsyD004827EFO:0000474epilepsy1ClinicalTrials
Diabetes MellitusD003920EFO:0000400diabetes mellitus4ATC
ClinicalTrials
Diabetes Mellitus, Type 2D003924EFO:0001360type II diabetes mellitus3ClinicalTrials

Clinical Data

ClinicalTrials.gov GLICLAZIDE
The Cochrane Collaboration GLICLAZIDE

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Target Predictions

The two tables below display ChEMBL single-protein targets which are predicted to interact with CHEMBL427216. A 1uM and 10 uM cut-off have been applied to ChEMBL bioactivity data used to generate the respective models and the yellow coloured rows correspond to genuine predictions, i.e. targets not included in the original training set for this compound.


1uM


ChEMBL_ID Target Name Organism Score
CHEMBL333 Matrix metalloproteinase-2 Homo sapiens 0.562
CHEMBL321 Matrix metalloproteinase 9 Homo sapiens 0.238

10uM


ChEMBL_ID Target Name Organism Score
CHEMBL333 Matrix metalloproteinase-2 Homo sapiens 0.277
CHEMBL2026 Beta-lactamase AmpC Escherichia coli K-12 0.239
CHEMBL2069 Thromboxane A2 receptor Homo sapiens 0.214

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
323.4 323.1304 1.63 3 78.51 ACID


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
4 2 0 6 2 0


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
6.07 3.89 1.61 -.17 1 22 0.89

Structural Alerts

There are 2 structural alerts for CHEMBL427216. To view alerts please click here.

Compound Cross References

ATC A - ALIMENTARY TRACT AND METABOLISM
A10 - DRUGS USED IN DIABETES
A10B - BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
A10BB - Sulfonylureas
A10BB09 - gliclazide

ChemSpider ChemSpider:BOVGTQGAOIONJV-UHFFFAOYSA-N
PubChem SID: 144204141 SID: 170465698 SID: 26748918 SID: 26748919 SID: 26748920 SID: 49646130
Wikipedia Gliclazide

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL427216



ACToR 21187-98-4
ChEBI 31654
ChemicalBook CB5113462
DrugBank DB01120
DrugCentral 1299
eMolecules 538655
EPA CompTox Dashboard DTXSID9023095
Human Metabolome Database HMDB0015252
IBM Patent System EE44AEE90D39779368B64B74A3915028
LINCS LSM-5096
Mcule MCULE-7993816491
MolPort MolPort-002-507-779
Nikkaji J3.151H
PharmGKB PA10892
PubChem 3475
PubChem: Thomson Pharma 14826273
Selleck gliclazide-diamicron
SureChEMBL SCHEMBL16387

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/BOVGTQGAOIONJV-UHFFFAOYSA-N spacer
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