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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL384467
CHEMBL384467
Compound Name DEXAMETHASONE
ChEMBL Synonyms Dexacen-4 | DEXAMETHASONE METASULFOBENZOATE SODIUM | Dexacort | DEXACORTISYL | MAXITROL | Kortico Injection | GPPE EAR SPY | Mymethasone | OTOMIZE | SOFRADEX | DECASPRAY | DEXAFREE | DEXAMETHASONE INTENSOL | MARTAPAN | MAXIDEX | OZURDEX | DEXONE | DEXONE 0.5 | Dalalone | HEXADROL | TOBRADEX | AEROSEB-DEX | DECADERM | DEXAMETHASONE | DEXAMETHASONE PALMITATE | DEXONE 0.75 | ORADEXON | DECADRON | DECADRON-75 | DEXAMETHASONE VALERATE | SPERSADEX COMP | Neodecadron | Dexair | Decadron-LA | DEXSOL | DEXONE 4 | DEXONE 1.5 | FLUORMETHYLPREDNISOLONE | DROPODEX
Max Phase 4 (Approved)
Trade Names DECASPRAY | DEXAFREE | DEXAMETHASONE INTENSOL | MARTAPAN | MAXIDEX | OZURDEX | OTOMIZE | SOFRADEX | DEXACORTISYL | GPPE EAR SPY | Kortico Injection | MAXITROL | DEXONE 1.5 | DEXONE 4 | DEXSOL | SPERSADEX COMP | DECADRON | DECADRON-75 | DROPODEX | AEROSEB-DEX | DECADERM | DEXAMETHASONE | DEXONE 0.75 | ORADEXON | DEXONE | DEXONE 0.5 | Dalalone | HEXADROL | TOBRADEX
Molecular Formula C22H29FO5

Additional synonyms for CHEMBL384467 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H]( ...
Download SMILES
Standard InChI InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2) ...
Download InChI
Standard InChI Key UREBDLICKHMUKA-CXSFZGCWSA-N

Sources

  • AstraZeneca Deposited Data
  • British National Formulary
  • DrugMatrix
  • Gene Expression Atlas Compounds
  • Open TG-GATEs
  • Orange Book
  • Patent Bioactivity Data
  • PubChem BioAssays
  • Scientific Literature
  • TP-search Transporter Database
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Alternate Forms of Compound in ChEMBL


CHEMBL384467

Molecule Features

CHEMBL384467 compound icon
Drug Type:Natural Product-derived Rule of Five:Y First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:Y Parenteral:Y Topical:Y Black Box:N Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Glucocorticoid receptor agonist Glucocorticoid receptor PubMed PubMed PubMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
Arthritis, GoutyD015210EFO:0004274gout4DailyMed
DailyMed
AsthmaD001249EFO:0000270asthma4ClinicalTrials
DailyMed
DailyMed
DailyMed
BlepharitisD0017623ClinicalTrials
Brain NeoplasmsD001932EFO:0003833brain neoplasm2ClinicalTrials
Carcinoma, HepatocellularD006528EFO:0000182hepatocellular carcinoma3ClinicalTrials
Carcinoma, Squamous CellD002294EFO:0000707squamous cell carcinoma2ClinicalTrials
Colitis, UlcerativeD003093EFO:0000729ulcerative colitis4ClinicalTrials
DailyMed
DailyMed
EczemaD004485HP:0000964Eczema3ClinicalTrials
Graves DiseaseD006111EFO:0004237Graves disease1ClinicalTrials
Lichen PlanusD008010EFO:1000726lichen planus3ClinicalTrials
Lung NeoplasmsD008175EFO:0001071lung carcinoma3ClinicalTrials
Migraine without AuraD020326EFO:0005296migraine without aura1ClinicalTrials
Myelodysplastic SyndromesD009190EFO:0000198myelodysplastic syndrome2ClinicalTrials
Nasopharyngeal NeoplasmsD009303EFO:0004252nasopharyngeal neoplasm2ClinicalTrials
NeoplasmsD009369EFO:0000311cancer3ClinicalTrials
NeoplasmsD009369EFO:0000616neoplasm3ClinicalTrials
Optic NeuritisD009902EFO:0007405optic neuritis4DailyMed
DailyMed
PneumoniaD011014EFO:0003106pneumonia4ClinicalTrials
DailyMed
DailyMed
Pulmonary EosinophiliaD011657EFO:0007257eosinophilic pneumonia4DailyMed
DailyMed
Purpura, Schoenlein-HenochD011695EFO:1000965Henoch-Schoenlein purpura2ClinicalTrials
Renal Insufficiency, ChronicD051436EFO:0003884chronic kidney disease3ClinicalTrials
Rhinitis, Allergic, SeasonalD006255EFO:0003956seasonal allergic rhinitis4DailyMed
Rotator Cuff InjuriesD000070636EFO:1001250rotator cuff tear1ClinicalTrials
Wounds and InjuriesD014947EFO:0000546injury3ClinicalTrials
Adrenocortical HyperfunctionD000308EFO:1000797adrenal gland hyperfunction4DailyMed
Anemia, Sickle CellD000755Orphanet:232Sickle cell anemia3ClinicalTrials
Breast NeoplasmsD001943EFO:0003869breast neoplasm3ClinicalTrials
Bronchopulmonary DysplasiaD001997Orphanet:70589Bronchopulmonary dysplasia3ClinicalTrials
CataractD002386EFO:0001059cataract3ClinicalTrials
Dermatitis, ExfoliativeD0038734DailyMed
DailyMed
Endometrial NeoplasmsD016889EFO:0004230endometrial neoplasm2ClinicalTrials
Esophageal NeoplasmsD004938EFO:0002916esophageal carcinoma1ClinicalTrials
Glomerulosclerosis, Focal SegmentalD005923EFO:0004236focal segmental glomerulosclerosis3ClinicalTrials
GoutD006073EFO:0004274gout2ClinicalTrials
HeadacheD006261HP:0002315Headache3ClinicalTrials
Hodgkin DiseaseD006689EFO:0000183Hodgkins lymphoma3ClinicalTrials
Idiopathic Pulmonary FibrosisD054990EFO:0000768idiopathic pulmonary fibrosis2ClinicalTrials
KeratitisD0076344DailyMed
DailyMed
LeptospirosisD007922EFO:0007344leptospirosis2ClinicalTrials
Leukemia, LymphoidD007945EFO:0004289lymphoid leukemia2ClinicalTrials
Leukemia, Myeloid, AcuteD015470EFO:0000222acute myeloid leukemia3ClinicalTrials
Leukemia, Plasma CellD007952EFO:0006475plasma cell leukemia2ClinicalTrials
Lupus Erythematosus, SystemicD008180EFO:0002690systemic lupus erythematosus4DailyMed
DailyMed
Lymphoma, T-Cell, CutaneousD016410EFO:0002913Cutaneous T-cell lymphoma1ClinicalTrials
MalariaD008288EFO:0001068malaria3ClinicalTrials
NauseaD009325HP:0002018Nausea3ClinicalTrials
Nephrotic SyndromeD009404EFO:0004255nephrotic syndrome4ClinicalTrials
DailyMed
DailyMed
Ovarian NeoplasmsD010051EFO:0001075ovarian carcinoma3ClinicalTrials
Respiratory Tract DiseasesD012140EFO:0000684respiratory system disease2ClinicalTrials
Retinal Vein OcclusionD012170EFO:1001157retinal vein occlusion2ClinicalTrials
RetinoblastomaD012175Orphanet:790Retinoblastoma1ClinicalTrials
SarcomaD012509EFO:0000691sarcoma3ClinicalTrials
Stevens-Johnson SyndromeD013262EFO:0004276Stevens-Johnson syndrome4DailyMed
DailyMed
TonsillitisD0140692ClinicalTrials
Urinary Tract InfectionsD014552EFO:0003103urinary tract infection3ClinicalTrials
Waldenstrom MacroglobulinemiaD008258EFO:0002616macroglobulinemia3ClinicalTrials
Addison DiseaseD0002244DailyMed
Aortic CoarctationD001017EFO:1001267Aortic Coarctation1ClinicalTrials
AppendicitisD001064EFO:0007149appendicitis2ClinicalTrials
Arthritis, RheumatoidD001172EFO:0000685rheumatoid arthritis4DailyMed
DailyMed
CarcinomaD002277EFO:0000313carcinoma2ClinicalTrials
CholangiocarcinomaD018281EFO:1001961intrahepatic cholangiocarcinoma2ClinicalTrials
Colorectal NeoplasmsD015179EFO:0000365colorectal adenocarcinoma2ClinicalTrials
Conjunctivitis, AllergicD003233EFO:0007141allergic conjunctivitis4ClinicalTrials
DailyMed
DailyMed
Conjunctivitis, BacterialD003234EFO:1000829bacterial conjunctivitis3ClinicalTrials
Dermatitis HerpetiformisD003874EFO:1000684dermatitis herpetiformis4DailyMed
DailyMed
Erythema MultiformeD004892EFO:1000694erythema multiforme4DailyMed
DailyMed
Fasciitis, PlantarD036981EFO:1001909Plantar Fasciitis2ClinicalTrials
Graft vs Host DiseaseD006086EFO:0004599acute graft vs. host disease3ClinicalTrials
Herpes Zoster OphthalmicusD006563EFO:0007403ophthalmic herpes zoster4DailyMed
DailyMed
LeukemiaD007938EFO:0000565leukemia4ClinicalTrials
DailyMed
DailyMed
LymphomaD008223EFO:0000574lymphoma4ClinicalTrials
DailyMed
DailyMed
Meningitis, CryptococcalD016919EFO:0007228cryptococcal meningitis2ClinicalTrials
PainD010146EFO:0003843pain3ClinicalTrials
PemphigusD010392EFO:0004719pemphigus vulgaris4ClinicalTrials
DailyMed
DailyMed
Premature BirthD047928EFO:0003917premature birth2ClinicalTrials
Prostatic NeoplasmsD011471EFO:0000673prostate adenocarcinoma3ClinicalTrials
Rheumatic DiseasesD012216EFO:0005755rheumatic disease1ClinicalTrials
SarcomaD012509EFO:1001968soft tissue sarcoma3ClinicalTrials
Smoldering Multiple MyelomaD000075122EFO:0003073asymptomatic myeloma2ClinicalTrials
Adrenal InsufficiencyD0003091ClinicalTrials
AmyloidosisD000686EFO:1001875amyloidosis3ClinicalTrials
Anemia, AplasticD000741HP:0001915aplastic anemia4DailyMed
DailyMed
Anemia, HemolyticD000743EFO:0005558hemolytic anemia4DailyMed
DailyMed
BronchiolitisD001988HP:0011950Bronchiolitis3ClinicalTrials
BursitisD002062EFO:1000941frozen shoulder4ClinicalTrials
DailyMed
DailyMed
ChoroiditisD0028334DailyMed
DailyMed
Crohn DiseaseD003424EFO:0000384Crohn's disease4ClinicalTrials
DailyMed
DailyMed
Head and Neck NeoplasmsD006258EFO:0006859head and neck malignant neoplasia1ClinicalTrials
Hearing Loss, SensorineuralD006319EFO:1001176sensorineural hearing loss2ClinicalTrials
Heart FailureD006333EFO:0000373congestive heart failure1ClinicalTrials
Hematoma, Subdural, IntracranialD046648EFO:1001801intracranial subdural hematoma2ClinicalTrials
HemorrhageD006470MP:0001914hemorrhage2ClinicalTrials
InfectionD007239EFO:0000544infection3ClinicalTrials
InflammationD007249MP:0001845inflammation4ClinicalTrials
DailyMed
Leukemia, Lymphocytic, Chronic, B-CellD015451EFO:0000095chronic lymphocytic leukemia2ClinicalTrials
Liver CirrhosisD008103EFO:0001422cirrhosis of liver3ClinicalTrials
Lymphoma, FollicularD008224EFO:0000096neoplasm of mature B-cells3ClinicalTrials
Lymphoma, Mantle-CellD020522EFO:1001469Mantle cell lymphoma3ClinicalTrials
MelanomaD008545EFO:0000756melanoma2ClinicalTrials
Migraine DisordersD008881EFO:0003821migraine disorder3ClinicalTrials
MyocarditisD0092054DailyMed
DailyMed
NauseaD009325EFO:0006911Chemotherapy-induced nausea and vomiting3ClinicalTrials
Postoperative Nausea and VomitingD020250HP:0002017Nausea and vomiting3ClinicalTrials
Respiratory Distress Syndrome, AdultD012128EFO:1000637acute respiratory distress syndrome3ClinicalTrials
ScleritisD0154231ClinicalTrials
Uveitis, AnteriorD014606EFO:1000811anterior uveitis3ClinicalTrials
Vaginosis, BacterialD016585EFO:0003932bacterial vaginosis3ClinicalTrials
DeafnessD003638EFO:0001063deafness3ClinicalTrials
Deglutition DisordersD003680HP:0002015Dysphagia3ClinicalTrials
Dermatitis, ContactD003877EFO:0005319contact dermatitis4DailyMed
DailyMed
Dermatitis, SeborrheicD012628EFO:1000764seborrheic dermatitis4DailyMed
DailyMed
HELLP SyndromeD017359EFO:0007297HELLP syndrome3ClinicalTrials
Hernias, Diaphragmatic, CongenitalD065630EFO:0005207congenital heart disease3ClinicalTrials
IridocyclitisD0158634DailyMed
DailyMed
Liver DiseasesD008107EFO:0001421liver disease2ClinicalTrials
Lymphoma, Large B-Cell, DiffuseD016403EFO:0000403diffuse large B-cell lymphoma3ClinicalTrials
Lymphoma, T-Cell, PeripheralD016411EFO:0000211unspecified peripheral T-cell lymphoma2ClinicalTrials
Macular DegenerationD008268EFO:0001365age-related macular degeneration2ClinicalTrials
Meningeal CarcinomatosisD055756EFO:1001012leptomeningeal metastases1ClinicalTrials
MesotheliomaD008654EFO:0000588mesothelioma2ClinicalTrials
Pelvic Organ ProlapseD056887EFO:0004710pelvic organ prolapse3ClinicalTrials
Peptic UlcerD010437HP:0004398Peptic ulcer4DailyMed
DailyMed
Postoperative Nausea and VomitingD020250EFO:0004888post operative nausea and vomiting3ClinicalTrials
Precursor T-Cell Lymphoblastic Leukemia-LymphomaD054218EFO:1001830precursor T-cell lymphoblastic leukemia-lymphoma1ClinicalTrials
Prostatic NeoplasmsD011471EFO:0001663prostate carcinoma3ClinicalTrials
Rhinitis, Allergic, SeasonalD006255EFO:0005854allergic rhinitis4DailyMed
DailyMed
Serum SicknessD0127134DailyMed
DailyMed
Spondylitis, AnkylosingD013167EFO:0003898ankylosing spondylitis4DailyMed
DailyMed
Adrenal Hyperplasia, CongenitalD000312Orphanet:90794Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency4DailyMed
DailyMed
Amyloidosis, FamilialD028226Orphanet:85443AL amyloidosis3ClinicalTrials
Arthritis, JuvenileD001171EFO:0002609chronic childhood arthritis4DailyMed
DailyMed
Breast NeoplasmsD001943EFO:0000305breast carcinoma3ClinicalTrials
Carcinoma, Non-Small-Cell LungD002289EFO:0003060non-small cell lung carcinoma3ClinicalTrials
ChorioretinitisD0028254DailyMed
DailyMed
CysticercosisD003551EFO:0007231cysticercosis3ClinicalTrials
Fractures, BoneD050723EFO:0003931bone fracture3ClinicalTrials
HypersensitivityD006967EFO:0003785allergy3ClinicalTrials
IritisD007500EFO:1000997iritis4DailyMed
DailyMed
Leukemia, Biphenotypic, AcuteD015456EFO:0000209T-cell acute lymphoblastic leukemia2ClinicalTrials
Liposarcoma, MyxoidD018208EFO:0000613myxoid liposarcoma2ClinicalTrials
Lymphoma, Non-HodgkinD008228EFO:0005952non-Hodgkins lymphoma3ClinicalTrials
Macular EdemaD0082693ClinicalTrials
NauseaD009325EFO:0006912Radiation-induced nausea and vomiting3ClinicalTrials
Purpura, Thrombocytopenic, IdiopathicD016553EFO:0007160autoimmune thrombocytopenic purpura4ClinicalTrials
DailyMed
DailyMed
Rhinitis, Allergic, PerennialD012221EFO:1001417Rhinitis, Allergic, Perennial3ClinicalTrials
SciaticaD012585HP:0011868Sciatica2ClinicalTrials
Small Cell Lung CarcinomaD055752EFO:0000702small cell lung carcinoma3ClinicalTrials
SynovitisD0135854DailyMed
DailyMed
ThrombocytopeniaD013921HP:0001873thrombocytopenia4ClinicalTrials
DailyMed
DailyMed
TrichinellosisD014235EFO:0007520trichinosis4DailyMed
DailyMed
TuberculosisD014376Orphanet:3389Tuberculosis2ClinicalTrials
Urinary Bladder NeoplasmsD001749EFO:0000292bladder carcinoma2ClinicalTrials
Uveitis, PosteriorD015866EFO:1001119posterior uveitis4ClinicalTrials
DailyMed
DailyMed
AmyloidosisD000686Orphanet:314701Primary systemic amyloidosis3ClinicalTrials
Arthritis, PsoriaticD015535EFO:0003778psoriatic arthritis4DailyMed
Burkitt LymphomaD002051EFO:0000309Burkitts lymphoma2ClinicalTrials
Carcinoma, Squamous CellD002294EFO:0000181head and neck squamous cell carcinoma2ClinicalTrials
Diabetic RetinopathyD003930EFO:0003770diabetic retinopathy3ClinicalTrials
Encephalitis, Herpes SimplexD020803Orphanet:1930Herpetic encephalitis3ClinicalTrials
Eye DiseasesD005128EFO:0005752eye inflammation4ATC
ATC
GlaucomaD005901EFO:0000516glaucoma3ClinicalTrials
Hearing LossD034381EFO:0004238hearing loss2ClinicalTrials
Lymphohistiocytosis, HemophagocyticD051359Orphanet:158038Primary hemophagocytic lymphohistiocytosis3ClinicalTrials
Mycosis FungoidesD009182EFO:1001051mycosis fungoides4DailyMed
DailyMed
Nervous System DiseasesD009422EFO:0000618nervous system disease2ClinicalTrials
Ophthalmia, SympatheticD009879EFO:1001205sympathetic ophthalmia4DailyMed
DailyMed
POEMS SyndromeD016878EFO:1001115POEMS syndrome2ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-LymphomaD054198EFO:0000220acute lymphoblastic leukemia3ClinicalTrials
PsoriasisD011565EFO:0000676psoriasis4DailyMed
DailyMed
SarcoidosisD012507Orphanet:797Sarcoidosis4ClinicalTrials
DailyMed
DailyMed
TenosynovitisD013717EFO:1001435Tenosynovitis4DailyMed
DailyMed
Tooth DiseasesD014076EFO:1001216tooth disease0ClinicalTrials
Toxoplasmosis, OcularD014126EFO:0007399ocular toxoplasmosis3ClinicalTrials
Tuberculosis, PulmonaryD014397EFO:1000049pulmonary tuberculosis4DailyMed
DailyMed
Uveitis, IntermediateD015867EFO:1000986intermediate uveitis2ClinicalTrials
Vitreoretinopathy, ProliferativeD018630EFO:1001129proliferative vitreoretinopathy3ClinicalTrials
VomitingD0148393ClinicalTrials
Acne VulgarisD000152EFO:0003894acne4ATC
Adrenal Hyperplasia, CongenitalD000312Orphanet:418Congenital adrenal hyperplasia4ClinicalTrials
Brain EdemaD001929EFO:1000845brain edema2ClinicalTrials
Carcinoma, Renal CellD002292EFO:0000681renal cell carcinoma2ClinicalTrials
Dermatitis, AtopicD003876EFO:0000274atopic eczema4DailyMed
DailyMed
Dry Eye SyndromesD015352EFO:1000906dry eye syndrome2ClinicalTrials
Eye DiseasesD005128EFO:0003966eye disease4ClinicalTrials
Hematologic NeoplasmsD019337EFO:0001642lymphoid neoplasm2ClinicalTrials
HypercalcemiaD006934HP:0003072Hypercalcemia4DailyMed
DailyMed
Intracranial HypertensionD019586EFO:1000992intracranial hypertension2ClinicalTrials
Leukemia, Biphenotypic, AcuteD015456EFO:0000094B-cell acute lymphoblastic leukemia2ClinicalTrials
Leukemia, Promyelocytic, AcuteD015473EFO:0000224acute promyelocytic leukemia3ClinicalTrials
Lymphoma, Large-Cell, AnaplasticD017728EFO:0003032anaplastic large cell lymphoma2ClinicalTrials
Multiple MyelomaD009101EFO:0001378multiple myeloma3ClinicalTrials
Nasal ObstructionD015508HP:0001742Nasal obstruction4ATC
ATC
NeuralgiaD009437EFO:0005762neuropathic pain3ClinicalTrials
OsteoarthritisD010003EFO:0002506osteoarthritis4ClinicalTrials
DailyMed
DailyMed
Otitis MediaD010033EFO:0004992Otitis media3ClinicalTrials
Ovarian Hyperstimulation SyndromeD016471Orphanet:64739Ovarian hyperstimulation syndrome3ClinicalTrials
Pancreatic NeoplasmsD010190EFO:0002618pancreatic carcinoma2ClinicalTrials
PlasmacytomaD010954EFO:0006738plasmacytoma3ClinicalTrials
Rectal NeoplasmsD012004EFO:1000657rectum cancer2ClinicalTrials
Tennis ElbowD0137164DailyMed
DailyMed
Thyroiditis, SubacuteD013968EFO:1001194subacute thyroiditis4DailyMed
DailyMed
Tuberculosis, MeningealD014390EFO:1000039meningeal tuberculosis4DailyMed
DailyMed
Wet Macular DegenerationD057135EFO:0004683wet macular degeneration2ClinicalTrials
XerostomiaD0149872ClinicalTrials

Clinical Data

ClinicalTrials.gov DEXAMETHASONE
The Cochrane Collaboration DEXAMETHASONE

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Target Predictions

The two tables below display ChEMBL single-protein targets which are predicted to interact with CHEMBL384467. A 1uM and 10 uM cut-off have been applied to ChEMBL bioactivity data used to generate the respective models and the yellow coloured rows correspond to genuine predictions, i.e. targets not included in the original training set for this compound.


1uM


ChEMBL_ID Target Name Organism Score
CHEMBL2034 Glucocorticoid receptor Homo sapiens 1.000
CHEMBL3368 Glucocorticoid receptor Rattus norvegicus 1.000
CHEMBL3251 Nuclear factor NF-kappa-B p105 subunit Homo sapiens 1.000
CHEMBL4261 Hypoxia-inducible factor 1 alpha Homo sapiens 1.000
CHEMBL1293237 Bloom syndrome protein Homo sapiens 1.000
CHEMBL208 Progesterone receptor Homo sapiens 0.984
CHEMBL3072 Androgen Receptor Rattus norvegicus 0.974
CHEMBL4931 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase Homo sapiens 0.973
CHEMBL3746 11-beta-hydroxysteroid dehydrogenase 2 Homo sapiens 0.824
CHEMBL1978 Cytochrome P450 19A1 Homo sapiens 0.649
CHEMBL2391 11-beta-hydroxysteroid dehydrogenase 1 Rattus norvegicus 0.543
CHEMBL3056 Androgen Receptor Mus musculus 0.293
CHEMBL332 Matrix metalloproteinase-1 Homo sapiens 0.254



10uM


ChEMBL_ID Target Name Organism Score
CHEMBL2034 Glucocorticoid receptor Homo sapiens 1.000
CHEMBL3368 Glucocorticoid receptor Rattus norvegicus 1.000
CHEMBL3251 Nuclear factor NF-kappa-B p105 subunit Homo sapiens 1.000
CHEMBL4261 Hypoxia-inducible factor 1 alpha Homo sapiens 1.000
CHEMBL1697668 Solute carrier organic anion transporter family member 1B1 Homo sapiens 1.000
CHEMBL1743121 Solute carrier organic anion transporter family member 1B3 Homo sapiens 1.000
CHEMBL2027 Niemann-Pick C1-like protein 1 Homo sapiens 1.000
CHEMBL3491 Cytochrome P450 2J2 Homo sapiens 1.000
CHEMBL3072 Androgen Receptor Rattus norvegicus 1.000
CHEMBL1293237 Bloom syndrome protein Homo sapiens 1.000
CHEMBL4931 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase Homo sapiens 0.994
CHEMBL208 Progesterone receptor Homo sapiens 0.992
CHEMBL1828 DNA polymerase alpha subunit Homo sapiens 0.990
CHEMBL1871 Androgen Receptor Homo sapiens 0.927
CHEMBL2391 11-beta-hydroxysteroid dehydrogenase 1 Rattus norvegicus 0.926
CHEMBL1978 Cytochrome P450 19A1 Homo sapiens 0.915
CHEMBL3746 11-beta-hydroxysteroid dehydrogenase 2 Homo sapiens 0.825
CHEMBL1806 DNA topoisomerase II alpha Homo sapiens 0.726
CHEMBL340 Cytochrome P450 3A4 Homo sapiens 0.709
CHEMBL5412 C-C chemokine receptor type 2 Mus musculus 0.421

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
392.5 392.1999 1.9 2 94.83 NEUTRAL


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
5 3 0 5 3 0


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
12.13 - 2.03 2.03 0 28 0.67

Structural Alerts

There are 5 structural alerts for CHEMBL384467. To view alerts please click here.

Compound Cross References

ATC D - DERMATOLOGICALS
D07 - CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07X - CORTICOSTEROIDS, OTHER COMBINATIONS
D07XB - Corticosteroids, moderately potent, other combinations
D07XB05 - dexamethasone

S - SENSORY ORGANS
S01 - OPHTHALMOLOGICALS
S01C - ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB - Corticosteroids/antiinfectives/mydriatics in combination
S01CB01 - dexamethasone

R - RESPIRATORY SYSTEM
R01 - NASAL PREPARATIONS
R01A - DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AD - Corticosteroids
R01AD53 - dexamethasone, combinations

H - SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 - CORTICOSTEROIDS FOR SYSTEMIC USE
H02A - CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB - Glucocorticoids
H02AB02 - dexamethasone

A - ALIMENTARY TRACT AND METABOLISM
A01 - STOMATOLOGICAL PREPARATIONS
A01A - STOMATOLOGICAL PREPARATIONS
A01AC - Corticosteroids for local oral treatment
A01AC02 - dexamethasone

D - DERMATOLOGICALS
D10 - ANTI-ACNE PREPARATIONS
D10A - ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AA - Corticosteroids, combinations for treatment of acne
D10AA03 - dexamethasone

D - DERMATOLOGICALS
D07 - CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A - CORTICOSTEROIDS, PLAIN
D07AB - Corticosteroids, moderately potent (group II)
D07AB19 - dexamethasone

S - SENSORY ORGANS
S02 - OTOLOGICALS
S02B - CORTICOSTEROIDS
S02BA - Corticosteroids
S02BA06 - dexamethasone

S - SENSORY ORGANS
S03 - OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
S03B - CORTICOSTEROIDS
S03BA - Corticosteroids
S03BA01 - dexamethasone

R - RESPIRATORY SYSTEM
R01 - NASAL PREPARATIONS
R01A - DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AD - Corticosteroids
R01AD03 - dexamethasone

C - CARDIOVASCULAR SYSTEM
C05 - VASOPROTECTIVES
C05A - AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA - Corticosteroids
C05AA09 - dexamethasone

S - SENSORY ORGANS
S01 - OPHTHALMOLOGICALS
S01B - ANTIINFLAMMATORY AGENTS
S01BA - Corticosteroids, plain
S01BA01 - dexamethasone

ChemSpider ChemSpider:UREBDLICKHMUKA-CXSFZGCWSA-N
DailyMed dexamethasone
PubChem SID: 144207320 SID: 17389945 SID: 26752876 SID: 26752877 SID: 26752878 SID: 56314873 SID: 56320685 SID: 92119
Wikipedia Dexamethasone

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL384467



ACToR 23495-06-9 137098-19-2
Atlas dexamethasone
BindingDB 18207
Brenda 48978 1159 48979
ChEBI 41879
ChemicalBook CB4261243
DrugBank DB01234
DrugCentral 824
eMolecules 29541178 31411022 30067429 497104
EPA CompTox Dashboard DTXSID3020384
FDA SRS 7S5I7G3JQL
Guide to Pharmacology 2768 3447
Human Metabolome Database HMDB0015364
IBM Patent System E8CBFAF221AF51FDD2082C42600CCD08
KEGG Ligand C15643
LINCS LSM-5512
Mcule MCULE-4773827191
MolPort MolPort-003-846-433
NIH Clinical Collection SAM002548948
Nikkaji J1.356K
PDBe DEX
PharmGKB PA449247
PubChem 5743
PubChem: Drugs of the Future 12012603
PubChem: Thomson Pharma 14805314 14805313
Selleck Dexamethasone
SureChEMBL SCHEMBL3774
ZINC ZINC000003875332

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/UREBDLICKHMUKA-CXSFZGCWSA-N spacer
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