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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL2364637
CHEMBL2364637
Compound Name TENOFOVIR ALAFENAMIDE FUMARATE
ChEMBL Synonyms GS-734003 | Tenofovir Alafenamide Fumarate
Max Phase 4 (Approved)
Trade Names
Molecular Formula C46H62N12O14P2

Additional synonyms for CHEMBL2364637 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES CC(C)OC(=O)[C@H](C)N[P@](=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)Oc3 ...
Download SMILES
Standard InChI InChI=1S/2C21H29N6O5P.C4H4O4/c2*1-14(2)31-21(28)16(4)26-33(2 ...
Download InChI
Standard InChI Key SVUJNSGGPUCLQZ-FQQAACOVSA-N

Mechanism of Action

Mechanism of Action ChEMBL Target References
Human immunodeficiency virus type 1 reverse transcriptase inhibitor Human immunodeficiency virus type 1 reverse transcriptase DailyMed

Indications for CHEMBL2364637

MESH Heading MESH ID EFO ID EFO Term Max phase for indication
HIV INFECTIONSD015658EFO:0000180HIV-1 INFECTION4

Molecule Features

CHEMBL2364637 compound icon
Drug Type:Natural Product Rule of Five:Y First In Class:N Chirality:Single Stereoisomer Prodrug:Y Oral:Y Parenteral:N Topical:N Black Box:Y Availability Type:Prescription-only

Clinical Data

Number of clinical trials registered at clinicaltrials.gov
Number of reviews at The Cochrane Collaboration
Number of entries at British National Formulary

Structural Alerts

There are 5 structural alerts for CHEMBL2364637. To view alerts please click here.

Alternate Forms of Compound in ChEMBL


CHEMBL2364637

Target Predictions

The two tables below display ChEMBL single-protein targets which are predicted to interact with CHEMBL2364637. A 1uM and 10 uM cut-off have been applied to ChEMBL bioactivity data used to generate the respective models and the yellow coloured rows correspond to genuine predictions, i.e. targets not included in the original training set for this compound.


1uM


ChEMBL_ID Target Name Organism Score
CHEMBL2664 Adenosylhomocysteinase Homo sapiens 1.000
CHEMBL5662 2,3-dihydroxybenzoate-AMP ligase Mycobacterium tuberculosis 1.000
CHEMBL2966 Adenosine deaminase Bos taurus 1.000
CHEMBL3975 Fructose-1,6-bisphosphatase Homo sapiens 0.994
CHEMBL1781862 Calmodulin-domain protein kinase 1 Toxoplasma gondii 0.989
CHEMBL1293237 Bloom syndrome protein Homo sapiens 0.987
CHEMBL2998 P2X purinoceptor 3 Homo sapiens 0.802



10uM


ChEMBL_ID Target Name Organism Score
CHEMBL2664 Adenosylhomocysteinase Homo sapiens 1.000
CHEMBL5662 2,3-dihydroxybenzoate-AMP ligase Mycobacterium tuberculosis 1.000
CHEMBL3975 Fructose-1,6-bisphosphatase Homo sapiens 0.997
CHEMBL6069 Pantothenate synthetase Mycobacterium tuberculosis 0.987
CHEMBL2966 Adenosine deaminase Bos taurus 0.987
CHEMBL1795117 Histone-lysine N-methyltransferase, H3 lysine-79 specific Homo sapiens 0.982
CHEMBL1781862 Calmodulin-domain protein kinase 1 Toxoplasma gondii 0.981
CHEMBL2360 Hypoxanthine-guanine phosphoribosyltransferase Homo sapiens 0.958
CHEMBL2998 P2X purinoceptor 3 Homo sapiens 0.923
CHEMBL267 Tyrosine-protein kinase SRC Homo sapiens 0.678
CHEMBL3251 Nuclear factor NF-kappa-B p105 subunit Homo sapiens 0.543
CHEMBL2284 Glyceraldehyde-3-phosphate dehydrogenase liver Homo sapiens 0.534
CHEMBL1293237 Bloom syndrome protein Homo sapiens 0.202

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
476.5 476.1937 1.53 12 153.29 NEUTRAL


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
9 2 0 11 3 1


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
13.4 .7 2.77 2.77 3 33 0.29

Compound Cross References

ChemSpider ChemSpider:SVUJNSGGPUCLQZ-FQQAACOVSA-N
DailyMed tenofovir alafenamide fumarate

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL2364637



ChEBI 90923
FDA SRS FWF6Q91TZO
PubChem 71492247
PubChem: Thomson Pharma 163471457

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/SVUJNSGGPUCLQZ-FQQAACOVSA-N spacer
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