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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1909283
CHEMBL1909283
Compound Name MEBANAZINE
ChEMBL Synonyms MEBANAZINE
Max Phase 4 (Approved)
Withdrawn Yes
Trade Names
Molecular Formula C8H12N2

Additional synonyms for CHEMBL1909283 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES CC(NN)c1ccccc1
Standard InChI InChI=1S/C8H12N2/c1-7(10-9)8-5-3-2-4-6-8/h2-7,10H,9H2,1H3
Standard InChI Key HHRZAEJMHSGZNP-UHFFFAOYSA-N

Sources

  • PubChem BioAssays
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names
  • Withdrawn Drugs

Alternate Forms of Compound in ChEMBL


CHEMBL1909283

Molecule Features

CHEMBL1909283 compound icon
Drug Type:Synthetic Small Molecule Rule of Five:Y First In Class:N Chirality:Racemic Mixture Prodrug:N Oral:N Parenteral:N Topical:N Black Box:N Availability Type:Withdrawn

Withdrawal Information

Year 1975
Country United Kingdom
Reason Hepatotoxicity; Drug Interaction
Class Hepatotoxicity

Mechanism of Action

Mechanism of Action ChEMBL Target References
Monoamine oxidase inhibitor Monoamine oxidase PubMed PubMed PubMed PubMed

Clinical Data

ClinicalTrials.gov MEBANAZINE
The Cochrane Collaboration MEBANAZINE

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
136.2 136.1 1.21 2 38.05 NEUTRAL


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
2 2 0 2 3 0


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
- 7.06 .67 .4 1 10 0.47

Structural Alerts

There are 5 structural alerts for CHEMBL1909283. To view alerts please click here.

Compound Cross References

ChemSpider ChemSpider:HHRZAEJMHSGZNP-UHFFFAOYSA-N
Wikipedia Mebanazine

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL1909283



ACToR 65-64-5
Brenda 107886
ChEBI 134728
DrugBank DB09248
DrugCentral 4865
eMolecules 35875007
IBM Patent System 1EC3F2448EC74AA0354E84C01608A514
MolPort MolPort-004-322-119
Nikkaji J4.839I
PubChem 6179
PubChem: Thomson Pharma 15114464
SureChEMBL SCHEMBL182461

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/HHRZAEJMHSGZNP-UHFFFAOYSA-N spacer
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