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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1504
CHEMBL1504
Compound Name TRIAMCINOLONE ACETONIDE
ChEMBL Synonyms SID855857 | Nasacort | Azmacort | Triderm | Triacet | Oralone | Kenalog | Aristocort | Triamcinolone Acetonide | SID56423119 | SID29215012
Max Phase 4 (Approved)
Trade Names Flutex | Trymex | Kenalog | Oracort | Oralone | Triacet | Triatex | Triderm | Vetalog | Azmacort | Nasacort | Triacort | Trivaris | Allernaze | Aristogel | Kenalog-H | Tri-Nasal | Triesence | Aristocort | Kenalog-10 | Kenalog-40 | Nasacort Aq | Aristocort A | Nasacort Hfa | Kenalog In Orabase | Triamcinolone Acetonide | Triamcinolone Acetonide In Absorbase
Molecular Formula C24H31FO6

Additional synonyms for CHEMBL1504 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[ ...
Download SMILES
Standard InChI InChI=1S/C24H31FO6/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8 ...
Download InChI
Standard InChI Key YNDXUCZADRHECN-JNQJZLCISA-N

Mechanism of Action

Mechanism of Action ChEMBL Target References
Glucocorticoid receptor agonist Glucocorticoid receptor DailyMed

Molecule Features

CHEMBL1504 compound icon
Drug Type:Natural Product Rule of Five:Y First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:N Parenteral:Y Topical:Y Black Box:Y Availability Type:Over-The-Counter

Clinical Trials for Compound

Number of clinical trials registered at clinicaltrials.gov

Alternate Forms of Compound in ChEMBL


CHEMBL1504

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Target Predictions

The two tables below display ChEMBL single-protein targets which are predicted to interact with CHEMBL1504. A 1uM and 10 uM cut-off have been applied to ChEMBL bioactivity data used to generate the respective models and the yellow coloured rows correspond to genuine predictions, i.e. targets not included in the original training set for this compound.


1uM


ChEMBL_ID Target Name Organism Score
CHEMBL2034 Glucocorticoid receptor Homo sapiens 1.000
CHEMBL3251 Nuclear factor NF-kappa-B p105 subunit Homo sapiens 1.000
CHEMBL3368 Glucocorticoid receptor Rattus norvegicus 1.000
CHEMBL4261 Hypoxia-inducible factor 1 alpha Homo sapiens 1.000
CHEMBL3305 Testis-specific androgen-binding protein Homo sapiens 1.000
CHEMBL1293237 Bloom syndrome protein Homo sapiens 1.000
CHEMBL3072 Androgen Receptor Rattus norvegicus 1.000
CHEMBL3746 11-beta-hydroxysteroid dehydrogenase 2 Homo sapiens 0.341
CHEMBL5162 Neuropeptide S receptor Homo sapiens 0.215



10uM


ChEMBL_ID Target Name Organism Score
CHEMBL3368 Glucocorticoid receptor Rattus norvegicus 1.000
CHEMBL2034 Glucocorticoid receptor Homo sapiens 1.000
CHEMBL4261 Hypoxia-inducible factor 1 alpha Homo sapiens 1.000
CHEMBL3251 Nuclear factor NF-kappa-B p105 subunit Homo sapiens 1.000
CHEMBL3072 Androgen Receptor Rattus norvegicus 1.000
CHEMBL3305 Testis-specific androgen-binding protein Homo sapiens 1.000
CHEMBL1697668 Solute carrier organic anion transporter family member 1B1 Homo sapiens 1.000
CHEMBL1743121 Solute carrier organic anion transporter family member 1B3 Homo sapiens 1.000
CHEMBL1293237 Bloom syndrome protein Homo sapiens 1.000
CHEMBL340 Cytochrome P450 3A4 Homo sapiens 0.983
CHEMBL5990 Breast cancer type 1 susceptibility protein Homo sapiens 0.977
CHEMBL4780 Acetylcholinesterase Torpedo californica 0.855
CHEMBL3318 Tyrosinase Agaricus bisporus 0.821
CHEMBL4696 Glycogen phosphorylase, muscle form Oryctolagus cuniculus 0.608
CHEMBL4931 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase Homo sapiens 0.317

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Ro5 Violations #Rotatable Bonds Ro3 Med Chem Friendly Molecular Species
434.5 434.2105 1.16 0 2 No No NEUTRAL


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms Num Alerts QED Weighted
12.87 - 2.43 2.43 0 31 0 0.68

Compound Cross References

ChemSpider ChemSpider:YNDXUCZADRHECN-JNQJZLCISA-N
DailyMed triamcinolone acetonide
PubChem SID: 29215012 SID: 56423119 SID: 855857
Wikipedia Triamcinolone_acetonide

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL1504



KEGG Ligand C08183
ChEBI 71418
NIH Clinical Collection SAM002564237
ZINC ZINC03875481
eMolecules 36754828 31590384 594687
FDA SRS F446C597KA
SureChem SureCN4689
Selleck Triamcinolone-Acetonide
PubChem: Thomson Pharma 14856756 14856757
PubChem 6436

UniChem REST Service Call: https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/YNDXUCZADRHECN-JNQJZLCISA-N spacer
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