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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1481
CHEMBL1481
Compound Name GLIMEPIRIDE
ChEMBL Synonyms HOE 490 | AMARYL | GLIMEPIRIDE
Max Phase 4 (Approved)
Trade Names AMARYL | Glimepiride
Molecular Formula C24H34N4O5S

Additional synonyms for CHEMBL1481 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES CCC1=C(C)CN(C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)N[C@@H]3CC[C@@H ...
Download SMILES
Standard InChI InChI=1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14 ...
Download InChI
Standard InChI Key WIGIZIANZCJQQY-RUCARUNLSA-N

Sources

  • AstraZeneca Deposited Data
  • British National Formulary
  • Curated Drug Pharmacokinetic Data
  • DrugMatrix
  • Orange Book
  • PubChem BioAssays
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Alternate Forms of Compound in ChEMBL


CHEMBL1481

Molecule Features

CHEMBL1481 compound icon
Drug Type:Synthetic Small Molecule Rule of Five:Y First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:Y Parenteral:N Topical:N Black Box:N Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Sulfonylurea receptor 1, Kir6.2 blocker Sulfonylurea receptor 1, Kir6.2 DailyMed PubMed PubMed PubMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
DIABETES MELLITUS, TYPE 2D003924Orphanet:552MODY4ClinicalTrials
DIABETES MELLITUS, TYPE 2D003924EFO:0001360TYPE II DIABETES MELLITUS4ClinicalTrials
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DIABETES MELLITUSD003920EFO:0000400DIABETES MELLITUS4ClinicalTrials

Clinical Data

ClinicalTrials.gov GLIMEPIRIDE
The Cochrane Collaboration GLIMEPIRIDE

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
490.6 490.225 3.78 7 133.06 ACID


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
5 3 0 9 3 0


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
5.1 - 3.45 1.51 1 34 0.54

Structural Alerts

There are 1 structural alerts for CHEMBL1481. To view alerts please click here.

Compound Cross References

ATC A - ALIMENTARY TRACT AND METABOLISM
A10 - DRUGS USED IN DIABETES
A10B - BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
A10BB - Sulfonylureas
A10BB12 - glimepiride

ChemSpider ChemSpider:WIGIZIANZCJQQY-RUCARUNLSA-N
DailyMed glimepiride
PubChem SID: 144204264 SID: 170464966 SID: 49648856
Wikipedia Glimepiride

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL1481



ACToR 93479-97-1
Brenda 147756
ChEBI 5383
DrugBank DB00222
DrugCentral 1300
EPA CompTox Dashboard DTXSID5040675
FDA SRS 6KY687524K
Guide to Pharmacology 6820
IBM Patent System B2558D7B10E55C59E3ADA545C5385ECA
LINCS LSM-44957
MolPort MolPort-003-847-587
NIH Clinical Collection SAM001246710
Nikkaji J35.096F
PubChem: Drugs of the Future 12013623
PubChem: Thomson Pharma 14908413
Selleck Glimepiride
SureChEMBL SCHEMBL16086
ZINC ZINC000100070954

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/WIGIZIANZCJQQY-RUCARUNLSA-N spacer
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