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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1472
CHEMBL1472
Compound Name PROTIRELIN
ChEMBL Synonyms SYNTHETIC TRH | PROTIRELIN TARTRATE | THYREL TRH | TRH-CAMBRIDGE | LOPREMONE | THYPINONE | PROTIRELIN | A-38579 | ABBOTT-38579
Max Phase 4 (Approved)
Trade Names TRH-CAMBRIDGE | THYPINONE | THYREL TRH
Molecular Formula C16H22N6O4

Additional synonyms for CHEMBL1472 found using NCI Chemical Identifier Resolver

Sources

  • British National Formulary
  • Orange Book
  • Patent Bioactivity Data
  • PubChem BioAssays
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Molecule Features

CHEMBL1472 compound icon
Drug Type:Oligopeptide Rule of Five:Y First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:N Parenteral:Y Topical:N Black Box:N Availability Type:Discontinued

Mechanism of Action

Mechanism of Action ChEMBL Target References
Thyrotropin-releasing hormone receptor agonist Thyrotropin-releasing hormone receptor DailyMed PubMed

Clinical Data

ClinicalTrials.gov PROTIRELIN
The Cochrane Collaboration PROTIRELIN

HELM Notation

CHEMBL1472 HELM Notation
PEPTIDE1{[Glp].H.P.[am]}$$$$

The ChEMBL HELM monomer library is available to download here.

For more details about HELM Notation, please visit the HELM Homepage.

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Target Predictions

The two tables below display ChEMBL single-protein targets which are predicted to interact with CHEMBL1472. A 1uM and 10 uM cut-off have been applied to ChEMBL bioactivity data used to generate the respective models and the yellow coloured rows correspond to genuine predictions, i.e. targets not included in the original training set for this compound.


1uM


ChEMBL_ID Target Name Organism Score
CHEMBL3600274 Thyrotropin-releasing hormone receptor 2 Mus musculus 1.000
CHEMBL3769 Trypsin I Bos taurus 1.000
CHEMBL3310 Histone deacetylase 11 Homo sapiens 1.000
CHEMBL3795 Melanocortin receptor 1 Homo sapiens 1.000
CHEMBL5103 Histone deacetylase 10 Homo sapiens 1.000
CHEMBL4074 Angiotensin-converting enzyme Oryctolagus cuniculus 1.000
CHEMBL270 Mu opioid receptor Rattus norvegicus 1.000
CHEMBL4644 Melanocortin receptor 3 Homo sapiens 0.998
CHEMBL1808 Angiotensin-converting enzyme Homo sapiens 0.997
CHEMBL2625 Angiotensin-converting enzyme Rattus norvegicus 0.996
CHEMBL4026 Signal transducer and activator of transcription 3 Homo sapiens 0.993
CHEMBL1801 Plasminogen Homo sapiens 0.991
CHEMBL3192 Histone deacetylase 8 Homo sapiens 0.942
CHEMBL4675 Tripeptidyl aminopeptidase Rattus norvegicus 0.871
CHEMBL1873 Tissue-type plasminogen activator Homo sapiens 0.818
CHEMBL3942 Neurokinin 1 receptor Cavia porcellus 0.586
CHEMBL4506 NAD-dependent deacetylase sirtuin 1 Homo sapiens 0.481
CHEMBL1937 Histone deacetylase 2 Homo sapiens 0.380
CHEMBL204 Thrombin Homo sapiens 0.308
CHEMBL2010635 Peptide deformylase Staphylococcus aureus 0.224



10uM


ChEMBL_ID Target Name Organism Score
CHEMBL2467 Thyrotropin-releasing hormone receptor Mus musculus 1.000
CHEMBL3600274 Thyrotropin-releasing hormone receptor 2 Mus musculus 1.000
CHEMBL4675 Tripeptidyl aminopeptidase Rattus norvegicus 1.000
CHEMBL3769 Trypsin I Bos taurus 1.000
CHEMBL2052031 Peptidyl-prolyl cis-trans isomerase FKBP5 Homo sapiens 1.000
CHEMBL3310 Histone deacetylase 11 Homo sapiens 1.000
CHEMBL3795 Melanocortin receptor 1 Homo sapiens 1.000
CHEMBL270 Mu opioid receptor Rattus norvegicus 1.000
CHEMBL4026 Signal transducer and activator of transcription 3 Homo sapiens 1.000
CHEMBL2625 Angiotensin-converting enzyme Rattus norvegicus 1.000
CHEMBL5103 Histone deacetylase 10 Homo sapiens 1.000
CHEMBL4074 Angiotensin-converting enzyme Oryctolagus cuniculus 1.000
CHEMBL4644 Melanocortin receptor 3 Homo sapiens 0.999
CHEMBL1808 Angiotensin-converting enzyme Homo sapiens 0.999
CHEMBL3656 Coagulation factor X Bos taurus 0.986
CHEMBL3192 Histone deacetylase 8 Homo sapiens 0.965
CHEMBL269 Delta opioid receptor Rattus norvegicus 0.960
CHEMBL4893 Hepatitis C virus NS3 protease/helicase Hepatitis C virus 0.959
CHEMBL3942 Neurokinin 1 receptor Cavia porcellus 0.929
CHEMBL2010635 Peptide deformylase Staphylococcus aureus 0.590

Compound Cross References

ATC V - VARIOUS
V04 - DIAGNOSTIC AGENTS
V04C - OTHER DIAGNOSTIC AGENTS
V04CJ - Tests for thyreoidea function
V04CJ02 - protirelin

ChemSpider ChemSpider:XNSAINXGIQZQOO-SRVKXCTJSA-N
DailyMed protirelin
PubChem SID: 144205492 SID: 29216304
Wikipedia Thyrotropin-releasing_hormone

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL1472



ACToR 24305-27-9
BindingDB 50072394
Brenda 95199 111086 4872 18097 66416 101617 12999 47513 6600
ChEBI 35940
DrugBank DB09421
DrugCentral 2316
eMolecules 5750666
EPA CompTox Dashboard DTXSID0023533
FDA SRS 5Y5F15120W
Guide to Pharmacology 2139
Human Metabolome Database HMDB0060080
IBM Patent System E32867DB4A6DBE59F2A47776ED53DEF6
KEGG Ligand C03958
Metabolights MTBLC35940
MolPort MolPort-006-124-300
Nikkaji J3.473H
PubChem 638678
PubChem: Thomson Pharma 16136709 14926032
Recon C03958
SureChEMBL SCHEMBL19825647 SCHEMBL33419
ZINC ZINC000004096261

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/XNSAINXGIQZQOO-SRVKXCTJSA-N spacer
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