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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1351
CHEMBL1351
Compound Name CARBOPLATIN
ChEMBL Synonyms CARBOPLATIN | JM-8 | Paraplatin
Max Phase 4 (Approved)
Trade Names CARBOPLATIN | PARAPLATIN
Molecular Formula C6H12N2O4Pt

Sources

  • British National Formulary
  • DrugMatrix
  • Open TG-GATEs
  • Orange Book
  • PubChem BioAssays
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Molecule Features

CHEMBL1351 compound icon
Drug Type:Synthetic Small Molecule Rule of Five:N First In Class:N Chirality:Unknown Prodrug:N Oral:N Parenteral:Y Topical:N Black Box:Y Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
DNA inhibitor DNA FDA

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
Carcinoma, Renal CellD002292EFO:0002890renal carcinoma3ClinicalTrials
Head and Neck NeoplasmsD006258EFO:0004284upper aerodigestive tract neoplasm3ClinicalTrials
Head and Neck NeoplasmsD006258EFO:0006859head and neck malignant neoplasia3ClinicalTrials
LeukemiaD007938EFO:0000565leukemia2ClinicalTrials
Leukemia, LymphoidD007945EFO:0004289lymphoid leukemia2ClinicalTrials
MedulloblastomaD008527EFO:0002939medulloblastoma3ClinicalTrials
MelanomaD008545EFO:0000389cutaneous melanoma3ClinicalTrials
Peritoneal NeoplasmsD010534EFO:1001100peritoneal neoplasm2ClinicalTrials
SarcomaD012509EFO:0000691sarcoma3ClinicalTrials
Skin NeoplasmsD012878EFO:0004198skin neoplasm3ClinicalTrials
Testicular NeoplasmsD013736EFO:0005088testicular carcinoma3ClinicalTrials
Thyroid NeoplasmsD013964EFO:0000641papillary thyroid carcinoma3ClinicalTrials
Urethral NeoplasmsD014523EFO:0003846urethral neoplasm3ClinicalTrials
Urinary Bladder NeoplasmsD001749EFO:0000292bladder carcinoma3ClinicalTrials
Brain NeoplasmsD001932EFO:0003833brain neoplasm2ClinicalTrials
Carcinoma, Intraductal, NoninfiltratingD002285EFO:0000432ductal carcinoma in situ2ClinicalTrials
Gallbladder NeoplasmsD005706EFO:0004606gallbladder neoplasm1ClinicalTrials
Lymphoma, FollicularD008224EFO:0000096neoplasm of mature B-cells2ClinicalTrials
MelanomaD008545EFO:0002617metastatic melanoma3ClinicalTrials
MesotheliomaD008654EFO:0000588mesothelioma3ClinicalTrials
Parathyroid NeoplasmsD010282EFO:1000456Parathyroid Gland Carcinoma1ClinicalTrials
Rectal NeoplasmsD012004EFO:1000657rectum cancer1ClinicalTrials
Skin DiseasesD012871EFO:0000701skin disease1ClinicalTrials
Small Cell Lung CarcinomaD055752EFO:0000702small cell lung carcinoma3ClinicalTrials
Uterine NeoplasmsD014594EFO:0003859uterine neoplasm3ClinicalTrials
Adrenocortical CarcinomaD018268EFO:0003093adrenocortical carcinoma1ClinicalTrials
Breast NeoplasmsD001943EFO:0003869breast neoplasm3ClinicalTrials
Breast Neoplasms, MaleD018567EFO:0006861male breast carcinoma2ClinicalTrials
Carcinoma, HepatocellularD006528EFO:0000182hepatocellular carcinoma3ClinicalTrials
Carcinoma, Large CellD018287EFO:0003050large cell lung carcinoma3ClinicalTrials
Carcinoma, Squamous CellD002294EFO:0000707squamous cell carcinoma3ClinicalTrials
Carcinoma, VerrucousD018289EFO:0007535verrucous carcinoma1ClinicalTrials
Colorectal NeoplasmsD015179EFO:1001951colorectal carcinoma3ClinicalTrials
DiseaseD004194EFO:0000408disease1ClinicalTrials
Endometrial NeoplasmsD016889EFO:1001512endometrial carcinoma3ClinicalTrials
Esophageal NeoplasmsD004938EFO:0005922esophageal squamous cell carcinoma3ClinicalTrials
GliosarcomaD018316EFO:1001465gliosarcoma2ClinicalTrials
Leukemia, Myeloid, AcuteD015470EFO:0000222acute myeloid leukemia2ClinicalTrials
Lymphoma, Non-HodgkinD008228EFO:0005952non-Hodgkins lymphoma3ClinicalTrials
Myelodysplastic SyndromesD009190EFO:0000198myelodysplastic syndrome2ClinicalTrials
NeuroblastomaD009447EFO:0000621neuroblastoma3ClinicalTrials
Ovarian NeoplasmsD010051EFO:0001075ovarian carcinoma4ClinicalTrials
DailyMed
DailyMed
DailyMed
DailyMed
RetinoblastomaD012175Orphanet:790Retinoblastoma3ClinicalTrials
Testicular NeoplasmsD013736EFO:0004281testicular neoplasm3ClinicalTrials
Uterine Cervical NeoplasmsD002583EFO:0001061cervical carcinoma3ClinicalTrials
Brain Stem NeoplasmsD020295EFO:1001767brain stem neoplasm2ClinicalTrials
Carcinoma, Merkel CellD015266EFO:1001471Merkel cell skin cancer2ClinicalTrials
Carcinoma, Non-Small-Cell LungD002289EFO:0003060non-small cell lung carcinoma3ClinicalTrials
Carcinoma, Squamous CellD002294EFO:0000708squamous cell lung carcinoma3ClinicalTrials
CholangiocarcinomaD018281EFO:1001961intrahepatic cholangiocarcinoma3ClinicalTrials
Choroid Plexus NeoplasmsD016545EFO:0007206choroid plexus cancer3ClinicalTrials
Esophageal NeoplasmsD004938EFO:0002916esophageal carcinoma3ClinicalTrials
GlioblastomaD005909EFO:0000519glioblastoma multiforme3ClinicalTrials
Inflammatory Breast NeoplasmsD058922EFO:1000984inflammatory breast carcinoma1ClinicalTrials
InsulinomaD007340EFO:0000549insulinoma1ClinicalTrials
LeiomyosarcomaD007890EFO:0000564leiomyosarcoma2ClinicalTrials
Lymphoma, Large B-Cell, DiffuseD016403EFO:0000403diffuse large B-cell lymphoma2ClinicalTrials
MesotheliomaD008654EFO:0000770malignant pleural mesothelioma3ClinicalTrials
Neoplasms, Germ Cell and EmbryonalD009373EFO:0000514germ cell tumor2ClinicalTrials
Pleural EffusionD0109961ClinicalTrials
Salivary Gland NeoplasmsD012468EFO:0003826salivary gland neoplasm2ClinicalTrials
Stomach NeoplasmsD013274EFO:0000178gastric carcinoma2ClinicalTrials
Ureteral NeoplasmsD014516EFO:0003844ureteral neoplasm2ClinicalTrials
Anus NeoplasmsD001005EFO:0003835anal neoplasm1ClinicalTrials
Bile Duct NeoplasmsD001650EFO:0005540bile duct carcinoma1ClinicalTrials
HistiocytomaD051642EFO:0005561histiocytoma3ClinicalTrials
Lymphoma, Large-Cell, AnaplasticD017728EFO:0003032anaplastic large cell lymphoma1ClinicalTrials
NeoplasmsD009369EFO:0000616neoplasm3ClinicalTrials
Pancreatic NeoplasmsD010190EFO:0002618pancreatic carcinoma1ClinicalTrials
Pericardial EffusionD010490EFO:0007298hemopericardium1ClinicalTrials
Prostatic NeoplasmsD011471EFO:0001663prostate carcinoma2ClinicalTrials
SarcomaD012509EFO:1001968soft tissue sarcoma3ClinicalTrials
Thyroid NeoplasmsD013964EFO:0002892thyroid carcinoma3ClinicalTrials
Uterine Cervical NeoplasmsD002583EFO:0001416cervical adenocarcinoma3ClinicalTrials
Adenocarcinoma, Bronchiolo-AlveolarD002282EFO:0000308bronchoalveolar adenocarcinoma2ClinicalTrials
Carcinoma, Renal CellD002292EFO:0000681renal cell carcinoma3ClinicalTrials
Endometrial NeoplasmsD016889EFO:0004230endometrial neoplasm3ClinicalTrials
Gestational Trophoblastic DiseaseD031901Orphanet:59305Gestational trophoblastic neoplasm3ClinicalTrials
HIV InfectionsD015658EFO:0000764HIV infection1ClinicalTrials
Hereditary Breast and Ovarian Cancer SyndromeD061325Orphanet:145Hereditary breast and ovarian cancer syndrome2ClinicalTrials
Lung NeoplasmsD008175EFO:0001071lung carcinoma3ClinicalTrials
LymphomaD008223EFO:0000574lymphoma3ClinicalTrials
MelanomaD008545EFO:0000756melanoma3ClinicalTrials
Neuroectodermal Tumors, PrimitiveD018242EFO:0005235primitive neuroectodermal tumor3ClinicalTrials
OligodendrogliomaD009837EFO:0000630oligoastrocytoma2ClinicalTrials
Ovarian NeoplasmsD010051Orphanet:398934Malignant epithelial tumor of ovary4ClinicalTrials
Prostatic NeoplasmsD011471EFO:0000196metastatic prostate cancer2ClinicalTrials
SomatostatinomaD013005EFO:1001187somatostatinoma1ClinicalTrials
AdenocarcinomaD000230EFO:0000228adenocarcinoma1ClinicalTrials
AstrocytomaD001254EFO:0002499anaplastic astrocytoma2ClinicalTrials
Carcinoma, Squamous CellD002294EFO:0000181head and neck squamous cell carcinoma3ClinicalTrials
EpendymomaD004806EFO:1000028ependymoma3ClinicalTrials
Fallopian Tube NeoplasmsD005185EFO:1000251Fallopian Tube Carcinoma2ClinicalTrials
Genital Neoplasms, FemaleD005833EFO:1001331Genital neoplasm, female1ClinicalTrials
Laryngeal NeoplasmsD007822EFO:0003817laryngeal neoplasm2ClinicalTrials
Lymphoma, Mantle-CellD020522EFO:1001469Mantle cell lymphoma1ClinicalTrials
NeoplasmsD009369EFO:0000311cancer3ClinicalTrials
OligodendrogliomaD009837EFO:0002501anaplastic oligodendroglioma2ClinicalTrials
Ovarian NeoplasmsD010051EFO:0003893ovarian neoplasm4ClinicalTrials
Vaginal NeoplasmsD014625EFO:1001447Vaginal neoplasm1ClinicalTrials
Vulvar NeoplasmsD014846EFO:0002921vulvar carcinoma1ClinicalTrials
Adenocarcinoma, FollicularD018263EFO:0000501follicular thyroid carcinoma1ClinicalTrials
Breast NeoplasmsD001943EFO:0000305breast carcinoma3ClinicalTrials
Burkitt LymphomaD002051EFO:0000309Burkitts lymphoma2ClinicalTrials
CarcinomaD002277EFO:0000313carcinoma3ClinicalTrials
Colorectal NeoplasmsD015179EFO:0000365colorectal adenocarcinoma3ClinicalTrials
GliomaD005910EFO:0000326central nervous system cancer3ClinicalTrials
Hodgkin DiseaseD006689EFO:0000183Hodgkins lymphoma2ClinicalTrials
Multiple MyelomaD009101EFO:0001378multiple myeloma1ClinicalTrials
Nasopharyngeal NeoplasmsD009303EFO:0004252nasopharyngeal neoplasm3ClinicalTrials
OsteosarcomaD012516EFO:0000637osteosarcoma2ClinicalTrials
Prostatic NeoplasmsD011471EFO:0000673prostate adenocarcinoma2ClinicalTrials
Triple Negative Breast NeoplasmsD064726EFO:0005537triple-negative breast cancer2ClinicalTrials
Urogenital NeoplasmsD014565EFO:0003863urogenital neoplasm3ClinicalTrials

Clinical Data

ClinicalTrials.gov CARBOPLATIN
The Cochrane Collaboration CARBOPLATIN

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Compound Cross References

ATC L - ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 - ANTINEOPLASTIC AGENTS
L01X - OTHER ANTINEOPLASTIC AGENTS
L01XA - Platinum compounds
L01XA02 - carboplatin

ChemSpider ChemSpider Identifier not yet assigned
DailyMed carboplatin
PubChem SID: 26748613 SID: 26748614 SID: 26748615 SID: 50110983
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