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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1237023
CHEMBL1237023
Compound Name DENOSUMAB
ChEMBL Synonyms PROLIA | PROLIA, XGEVA | DENOSUMAB | XGEVA | Prolia, Ranmark XGEVA | AMG-162
Max Phase 4 (Approved)
Trade Names PROLIA, XGEVA | XGEVA | PROLIA | Prolia, Ranmark XGEVA

Sources

  • British National Formulary
  • Clinical Candidates
  • Manually Added Drugs
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Molecule Features

CHEMBL1237023 compound icon
Drug Type:Antibody Rule of Five:N First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:N Parenteral:Y Topical:N Black Box:N Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Tumor necrosis factor ligand superfamily member 11 inhibitor Tumor necrosis factor ligand superfamily member 11 DailyMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
Aortic Valve StenosisD001024EFO:0000266aortic stenosis2ClinicalTrials
HypercalcemiaD006934HP:0003072Hypercalcemia4DailyMed
HypersensitivityD006967EFO:0003785allergy1ClinicalTrials
MelanomaD008545EFO:0000756melanoma1ClinicalTrials
Neoplasm MetastasisD0093624DailyMed
Prostatic NeoplasmsD011471EFO:0001663prostate carcinoma3ClinicalTrials
Arthritis, RheumatoidD001172EFO:0000685rheumatoid arthritis3ClinicalTrials
Carcinoma, Non-Small-Cell LungD002289EFO:0003060non-small cell lung carcinoma2ClinicalTrials
Fractures, BoneD050723EFO:0003931bone fracture3ClinicalTrials
Bone Diseases, MetabolicD001851HP:0000938osteopenia3ClinicalTrials
Breast NeoplasmsD001943EFO:0000305breast carcinoma3ClinicalTrials
Infertility, MaleD007248EFO:0004248male infertility2ClinicalTrials
Osteogenesis ImperfectaD010013Orphanet:666Osteogenesis imperfecta3ClinicalTrials
OsteosarcomaD012516EFO:0000637osteosarcoma2ClinicalTrials
Carcinoma, Renal CellD002292EFO:0000681renal cell carcinoma3ClinicalTrials
GoutD006073EFO:0004274gout2ClinicalTrials
Histiocytosis, Langerhans-CellD006646EFO:1000318Langerhans Cell Histiocytosis2ClinicalTrials
Anorexia NervosaD000856EFO:0004215anorexia nervosa3ClinicalTrials
Breast NeoplasmsD001943EFO:0003869breast neoplasm3ClinicalTrials
NeoplasmsD009369EFO:0000311cancer1ClinicalTrials
Osteoporosis, PostmenopausalD015663EFO:0003854postmenopausal osteoporosis3ClinicalTrials
Lung NeoplasmsD008175EFO:0001071lung carcinoma3ClinicalTrials
Multiple MyelomaD009101EFO:0001378multiple myeloma2ClinicalTrials
Osteoarthritis, HipD015207EFO:1000786osteoarthritis, hip2ClinicalTrials
OsteoporosisD010024EFO:0003882osteoporosis4ClinicalTrials
DailyMed
Bone DiseasesD001847EFO:0004260bone disease4ATC
Crohn DiseaseD003424EFO:0000384Crohn's disease1ClinicalTrials

Clinical Data

ClinicalTrials.gov DENOSUMAB
The Cochrane Collaboration DENOSUMAB

Compound Cross References

ATC M - MUSCULO-SKELETAL SYSTEM
M05 - DRUGS FOR TREATMENT OF BONE DISEASES
M05B - DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
M05BX - Other drugs affecting bone structure and mineralization
M05BX04 - denosumab

ChemSpider ChemSpider Identifier not yet assigned
DailyMed denosumab
Wikipedia Denosumab
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