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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1237022
CHEMBL1237022
Compound Name TOCILIZUMAB
ChEMBL Synonyms ACTEMRA ROACTEMRA | ATLIZUMAB | MRA | R-1569 | RHPM-1 | TOCILIZUMAB | RG-1569 | Actemra | ROACTEMRA
Max Phase 4 (Approved)
Trade Names ACTEMRA ROACTEMRA | ROACTEMRA | Actemra

Sources

  • British National Formulary
  • Clinical Candidates
  • Manually Added Drugs
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Molecule Features

CHEMBL1237022 compound icon
Drug Type:Antibody Rule of Five:N First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:N Parenteral:Y Topical:N Black Box:Y Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Interleukin-6 receptor alpha subunit inhibitor Interleukin-6 receptor alpha subunit DailyMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
Arthritis, RheumatoidD001172EFO:0000685rheumatoid arthritis4ClinicalTrials
DailyMed
Castleman DiseaseD005871EFO:1001332Giant Lymph Node Hyperplasia2ClinicalTrials
Diabetes Mellitus, Type 1D003922EFO:0001359type I diabetes mellitus2ClinicalTrials
Fibrous Dysplasia of BoneD005357Orphanet:249Fibrous dysplasia of bone2ClinicalTrials
Giant Cell ArteritisD013700EFO:1001209temporal arteritis3ClinicalTrials
Graves OphthalmopathyD049970EFO:1001466Graves ophthalmopathy3ClinicalTrials
Hypertension, PulmonaryD006976EFO:0001361pulmonary hypertension2ClinicalTrials
Leukemia, Lymphocytic, Chronic, B-CellD015451EFO:0000095chronic lymphocytic leukemia1ClinicalTrials
Neuromyelitis OpticaD009471EFO:0004256neuromyelitis optica2ClinicalTrials
Ovarian NeoplasmsD010051EFO:0001075ovarian carcinoma1ClinicalTrials
PolymyositisD017285EFO:0003063polymyositis2ClinicalTrials
Sjogren's SyndromeD012859EFO:0000699Sjogren syndrome2ClinicalTrials
Depressive DisorderD003866EFO:0003761unipolar depression2ClinicalTrials
Erdheim-Chester DiseaseD031249EFO:1000926Erdheim-Chester disease2ClinicalTrials
Hematoma, Subdural, IntracranialD046648EFO:1001801intracranial subdural hematoma1ClinicalTrials
Immune System DiseasesD007154EFO:0000540immune system disease4ATC
LeukemiaD007938EFO:0000565leukemia2ClinicalTrials
Myocardial InfarctionD009203EFO:0000612myocardial infarction2ClinicalTrials
Renal Insufficiency, ChronicD051436EFO:0003884chronic kidney disease1ClinicalTrials
Uveitis, PosteriorD015866EFO:1001119posterior uveitis1ClinicalTrials
Behcet SyndromeD001528EFO:0003780Behcet's syndrome2ClinicalTrials
Takayasu ArteritisD013625EFO:1001857Takayasu arteritis3ClinicalTrials
Breast NeoplasmsD001943EFO:0000305breast carcinoma1ClinicalTrials
Familial Mediterranean FeverD010505Orphanet:342Familial Mediterranean fever2ClinicalTrials
HIV InfectionsD015658EFO:0000764HIV infection1ClinicalTrials
Leukemia, Myeloid, AcuteD015470EFO:0000222acute myeloid leukemia1ClinicalTrials
Lymphoma, Non-HodgkinD008228EFO:0005952non-Hodgkins lymphoma1ClinicalTrials
Scleroderma, SystemicD012595EFO:0000717systemic scleroderma3ClinicalTrials
Uveitis, IntermediateD015867EFO:1000986intermediate uveitis1ClinicalTrials
Pancreatic NeoplasmsD010190EFO:0002618pancreatic carcinoma2ClinicalTrials
Arthritis, JuvenileD001171EFO:0002609chronic childhood arthritis4ClinicalTrials
DailyMed
Diabetic RetinopathyD003930EFO:0003770diabetic retinopathy2ClinicalTrials
Graft vs Host DiseaseD006086EFO:0004599acute graft vs. host disease2ClinicalTrials
Lymphohistiocytosis, HemophagocyticD051359Orphanet:158038Primary hemophagocytic lymphohistiocytosis2ClinicalTrials
UveitisD014605EFO:1001231uveitis2ClinicalTrials
Carcinoma, HepatocellularD006528EFO:0000182hepatocellular carcinoma1ClinicalTrials
DermatomyositisD003882EFO:0000398dermatomyositis2ClinicalTrials
Multiple MyelomaD009101EFO:0001378multiple myeloma0ClinicalTrials
Polychondritis, RelapsingD011081EFO:1001148relapsing polychondritis2ClinicalTrials
Spondylitis, AnkylosingD013167EFO:0003898ankylosing spondylitis3ClinicalTrials
Still's Disease, Adult-OnsetD016706EFO:0007135adult-onset Still's disease2ClinicalTrials
Amyotrophic Lateral SclerosisD000690EFO:0000253amyotrophic lateral sclerosis2ClinicalTrials
SchizophreniaD012559EFO:0000692schizophrenia1ClinicalTrials

Clinical Data

ClinicalTrials.gov TOCILIZUMAB
The Cochrane Collaboration TOCILIZUMAB

Compound Cross References

ATC L - ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L04 - IMMUNOSUPPRESSANTS
L04A - IMMUNOSUPPRESSANTS
L04AC - Interleukin inhibitors
L04AC07 - tocilizumab

ChemSpider ChemSpider Identifier not yet assigned
DailyMed tocilizumab
Wikipedia Tocilizumab
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