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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1214124
CHEMBL1214124
Compound Name PERAMPANEL
ChEMBL Synonyms PERAMPANEL | E2007 | E-2007 | ER-155055-90 | FYCOMPA
Max Phase 4 (Approved)
Trade Names FYCOMPA
Molecular Formula C23H15N3O

Additional synonyms for CHEMBL1214124 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES O=C1N(C=C(C=C1c2ccccc2C#N)c3ccccn3)c4ccccc4
Standard InChI InChI=1S/C23H15N3O/c24-15-17-8-4-5-11-20(17)21-14-18(22-12-6 ...
Download InChI
Standard InChI Key PRMWGUBFXWROHD-UHFFFAOYSA-N

Sources

  • British National Formulary
  • Manually Added Drugs
  • Orange Book
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Alternate Forms of Compound in ChEMBL


CHEMBL1214124

Molecule Features

CHEMBL1214124 compound icon
Drug Type:Synthetic Small Molecule Rule of Five:Y First In Class:N Chirality:Achiral Molecule Prodrug:N Oral:Y Parenteral:N Topical:N Black Box:Y Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Glutamate receptor ionotropic AMPA antagonist Glutamate receptor ionotropic AMPA Expert

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
SEIZURESD012640HP:0001250SEIZURES3ClinicalTrials
DIABETIC NEUROPATHIESD003929EFO:1000783DIABETIC NEUROPATHY2ClinicalTrials
ESSENTIAL TREMORD020329EFO:0003108ESSENTIAL TREMOR2ClinicalTrials
PARKINSON DISEASED010300EFO:0002508PARKINSON'S DISEASE3ClinicalTrials
NEURALGIAD009437EFO:0005762NEUROPATHIC PAIN2ClinicalTrials
EPILEPSYD004827EFO:0000474EPILEPSY4DailyMed
ATC
ClinicalTrials
MIGRAINE DISORDERSD008881EFO:0003821MIGRAINE DISORDER2ClinicalTrials
TORTICOLLISD014103HP:0000473TORTICOLLIS1ClinicalTrials

Clinical Data

ClinicalTrials.gov PERAMPANEL
The Cochrane Collaboration PERAMPANEL

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Target Predictions

The two tables below display ChEMBL single-protein targets which are predicted to interact with CHEMBL1214124. A 1uM and 10 uM cut-off have been applied to ChEMBL bioactivity data used to generate the respective models and the yellow coloured rows correspond to genuine predictions, i.e. targets not included in the original training set for this compound.


1uM


ChEMBL_ID Target Name Organism Score
CHEMBL3227 Metabotropic glutamate receptor 5 Homo sapiens 0.999
CHEMBL3649 Xanthine dehydrogenase Bos taurus 0.999
CHEMBL2564 Metabotropic glutamate receptor 5 Rattus norvegicus 0.872
CHEMBL3772 Metabotropic glutamate receptor 1 Homo sapiens 0.432

10uM


ChEMBL_ID Target Name Organism Score
CHEMBL3649 Xanthine dehydrogenase Bos taurus 0.999
CHEMBL3227 Metabotropic glutamate receptor 5 Homo sapiens 0.998
CHEMBL3772 Metabotropic glutamate receptor 1 Homo sapiens 0.958
CHEMBL3356 Cytochrome P450 1A2 Homo sapiens 0.631
CHEMBL2564 Metabotropic glutamate receptor 5 Rattus norvegicus 0.520
CHEMBL1293226 Lysine-specific demethylase 4D-like Homo sapiens 0.386

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
349.4 349.1215 3.57 3 56.99 NEUTRAL


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
3 0 0 4 0 0


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
- 4.73 1.36 1.36 3 27 0.73

Structural Alerts

There are 1 structural alerts for CHEMBL1214124. To view alerts please click here.

Compound Cross References

ATC N - NERVOUS SYSTEM
N03 - ANTIEPILEPTICS
N03A - ANTIEPILEPTICS
N03AX - Other antiepileptics
N03AX22 - perampanel

ChemSpider ChemSpider:PRMWGUBFXWROHD-UHFFFAOYSA-N
DailyMed perampanel
Wikipedia Perampanel

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL1214124



ACToR 380917-97-5
ChEBI 71013
DrugBank DB08883
DrugCentral 4684
EPA CompTox Dashboard DTXSID80191501
FDA SRS H821664NPK
Guide to Pharmacology 7050
IBM Patent System 3CE4041CDA26AF2A644E1A42F0A5E469
MolPort MolPort-035-395-270
Nikkaji J2.400.987D
PDBe 6ZP
PubChem 9924495
PubChem: Drugs of the Future 136349971
PubChem: Thomson Pharma 14896254
SureChEMBL SCHEMBL194370
ZINC ZINC000030691797

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/PRMWGUBFXWROHD-UHFFFAOYSA-N spacer
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