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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1201825
CHEMBL1201825
Compound Name RANIBIZUMAB
ChEMBL Synonyms RG-3645 | Lucentis | RANIBIZUMAB | RHUFAB | FAB-12 VARIANT Y0317
Max Phase 4 (Approved)
Trade Names Lucentis

Sources

  • British National Formulary
  • Clinical Candidates
  • Manually Added Drugs
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Molecule Features

CHEMBL1201825 compound icon
Drug Type:Antibody Rule of Five:N First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:N Parenteral:Y Topical:N Black Box:N Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Vascular endothelial growth factor A inhibitor Vascular endothelial growth factor A DailyMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
GLAUCOMAD005901EFO:0000516GLAUCOMA2ClinicalTrials
RETINAL DISEASESD012164EFO:0003839RETINOPATHY2ClinicalTrials
RETINAL NEOVASCULARIZATIOND015861EFO:0005753OCULAR VASCULAR DISORDER4ATC
RETINAL VEIN OCCLUSIOND012170EFO:1001157RETINAL VEIN OCCLUSION4ClinicalTrials
DIABETIC RETINOPATHYD003930EFO:0003770DIABETIC RETINOPATHY4ClinicalTrials
DailyMed
MACULAR EDEMAD008269HP:0011505CYSTOID MACULAR EDEMA4ClinicalTrials
WET MACULAR DEGENERATIOND057135EFO:0004683WET MACULAR DEGENERATION4ClinicalTrials
DailyMed
MACULAR DEGENERATIOND008268EFO:0001365AGE-RELATED MACULAR DEGENERATION4ClinicalTrials
OPTIC NEUROPATHY, ISCHEMICD018917EFO:1000809ANTERIOR ISCHEMIC OPTIC NEUROPATHY1ClinicalTrials
RETINOPATHY OF PREMATURITYD012178EFO:1001158RETINOPATHY OF PREMATURITY3ClinicalTrials
MACULAR EDEMAD008269HP:0040049MACULAR EDEMA4ClinicalTrials
DailyMed
MYOPIAD009216HP:0000545MYOPIA1ClinicalTrials
MELANOMAD008545EFO:0000756MELANOMA2ClinicalTrials
CORNEAL NEOVASCULARIZATIOND016510EFO:1000880CORNEAL NEOVASCULARIZATION1ClinicalTrials
DIABETES MELLITUSD003920EFO:0000400DIABETES MELLITUS2ClinicalTrials
HISTOPLASMOSISD006660EFO:0007310HISTOPLASMOSIS2ClinicalTrials
PTERYGIUMD011625EFO:0000678PTERYGIUM2ClinicalTrials

Clinical Data

ClinicalTrials.gov RANIBIZUMAB
The Cochrane Collaboration RANIBIZUMAB

Biological Sequence

Description Sequence
Ranibizumab fab fragment DIQLTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKVLIYFTSSLHSGVPS RFSGSGSGTDFTLTISSLQPEDFATYYCQQYSTVPWTFGQGTKVEIKRTVAAPSVFIFPP SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLT LSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE
Ranibizumab light chain EVQLVESGGGLVQPGGSLRLSCAASGYDFTHYGMNWVRQAPGKGLEWVGWINTYTGEPTY AADFKRRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCAKYPYYYGTSHWYFDVWGQGTLVT VSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLY SLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK

Compound Cross References

ATC S - SENSORY ORGANS
S01 - OPHTHALMOLOGICALS
S01L - OCULAR VASCULAR DISORDER AGENTS
S01LA - Antineovascularisation agents
S01LA04 - ranibizumab

ChemSpider ChemSpider Identifier not yet assigned
DailyMed ranibizumab
Wikipedia Ranibizumab
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