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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1201575
CHEMBL1201575
Compound Name EFALIZUMAB
ChEMBL Synonyms ANTI-CD11A | RAPTIVA | EFALIZUMAB | HU1124
Max Phase 4 (Approved)
Withdrawn Yes
Trade Names RAPTIVA

Sources

  • British National Formulary
  • Clinical Candidates
  • Manually Added Drugs
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification
  • Withdrawn Drugs

Molecule Features

CHEMBL1201575 compound icon
Drug Type:Antibody Rule of Five:N First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:N Parenteral:Y Topical:N Black Box:N Availability Type:Withdrawn

Withdrawal Information

Year 2009
Country United States
Reason Progressive multifocal leukoencephalopathy
Class Neurotoxicity

Mechanism of Action

Mechanism of Action ChEMBL Target References
Integrin alpha-L/beta-2 (LFA-1) inhibitor Integrin alpha-L/beta-2 (LFA-1) FDA

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
Diabetic RetinopathyD003930EFO:0003770diabetic retinopathy1ClinicalTrials
Lupus Erythematosus, SystemicD008180EFO:0002690systemic lupus erythematosus2ClinicalTrials
Diabetes Mellitus, Type 1D003922EFO:0001359type I diabetes mellitus2ClinicalTrials
Hidradenitis SuppurativaD017497EFO:1000710hidradenitis suppurativa1ClinicalTrials
AlopeciaD000505Orphanet:700Alopecia totalis2ClinicalTrials
Dermatitis, AtopicD003876EFO:0000274atopic eczema2ClinicalTrials
PsoriasisD011565EFO:0000676psoriasis3ClinicalTrials
Arthritis, RheumatoidD001172EFO:0000685rheumatoid arthritis2ClinicalTrials
Macular DegenerationD008268EFO:0001365age-related macular degeneration1ClinicalTrials
Sjogren's SyndromeD012859EFO:0000699Sjogren syndrome2ClinicalTrials
Arthritis, PsoriaticD015535EFO:0003778psoriatic arthritis1ClinicalTrials
Immune System DiseasesD007154EFO:0000540immune system disease4ATC
ClinicalTrials

Clinical Data

ClinicalTrials.gov EFALIZUMAB
The Cochrane Collaboration EFALIZUMAB

Compound Cross References

ATC L - ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L04 - IMMUNOSUPPRESSANTS
L04A - IMMUNOSUPPRESSANTS
L04AA - Selective immunosuppressants
L04AA21 - efalizumab

ChemSpider ChemSpider Identifier not yet assigned
Wikipedia Efalizumab
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