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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1201561
CHEMBL1201561
Compound Name PEGINTERFERON ALFA-2B
ChEMBL Synonyms Peg-Intron | PEGINTERFERON ALFA-2B | PEGINTRON
Max Phase 4 (Approved)
Trade Names PEGINTRON | Peg-Intron

Sources

  • Manually Added Drugs
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Molecule Features

CHEMBL1201561 compound icon
Drug Type:Oligopeptide Rule of Five:N First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:N Parenteral:Y Topical:N Black Box:Y Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Interferon alpha/beta receptor agonist Interferon alpha/beta receptor DailyMed PubMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
Head and Neck NeoplasmsD006258EFO:0006859head and neck malignant neoplasia2ClinicalTrials
Leukemia, Biphenotypic, AcuteD015456EFO:0000209T-cell acute lymphoblastic leukemia2ClinicalTrials
Neurofibromatosis 1D009456Orphanet:636Neurofibromatosis type 12ClinicalTrials
OsteosarcomaD012516EFO:0000637osteosarcoma3ClinicalTrials
CraniopharyngiomaD003397EFO:1000209Craniopharyngioma2ClinicalTrials
HIV InfectionsD015658EFO:0000180HIV-1 infection2ClinicalTrials
Hepatitis DD003699EFO:0007304hepatitis D3ClinicalTrials
Lymphoma, Mantle-CellD020522EFO:1001469Mantle cell lymphoma3ClinicalTrials
Multiple MyelomaD009101EFO:0001378multiple myeloma3ClinicalTrials
Renal InsufficiencyD0514371ClinicalTrials
Thrombocythemia, EssentialD013920EFO:0000479essential thrombocythemia3ClinicalTrials
GliomaD005910EFO:0000326central nervous system cancer2ClinicalTrials
MelanomaD008545EFO:0000756melanoma4ClinicalTrials
DailyMed
DailyMed
NeoplasmsD009369EFO:0000311cancer1ClinicalTrials
Polycythemia VeraD011087EFO:0002429polycythemia vera3ClinicalTrials
Carcinoid TumorD002276EFO:0004243carcinoid tumor2ClinicalTrials
Carcinoma, Renal CellD002292EFO:0000681renal cell carcinoma2ClinicalTrials
Hepatitis C, ChronicD019698EFO:0004220Chronic Hepatitis C infection4ClinicalTrials
DailyMed
DailyMed
Uterine Cervical NeoplasmsD002583EFO:0001061cervical carcinoma2ClinicalTrials
Carcinoma, Renal CellD002292EFO:0002890renal carcinoma2ClinicalTrials
Carcinoma, Squamous CellD002294EFO:0000707squamous cell carcinoma2ClinicalTrials
Hepatitis B, ChronicD019694EFO:0004239chronic hepatitis B infection3ClinicalTrials
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveD015464EFO:0000339chronic myelogenous leukemia3ClinicalTrials
MelanomaD008545EFO:0000389cutaneous melanoma4ClinicalTrials
AstrocytomaD001254EFO:0000272astrocytoma2ClinicalTrials
HIV InfectionsD015658EFO:0000764HIV infection2ClinicalTrials
LeukemiaD007938EFO:0000565leukemia2ClinicalTrials
LymphomaD008223EFO:0000574lymphoma1ClinicalTrials
Acquired Immunodeficiency SyndromeD000163EFO:0000765AIDS3ClinicalTrials
Carcinoma, HepatocellularD006528EFO:0000182hepatocellular carcinoma3ClinicalTrials
Hepatitis CD006526EFO:0003047hepatitis C infection3ClinicalTrials
MelanomaD008545EFO:0002617metastatic melanoma4ClinicalTrials
NeoplasmsD009369EFO:0000616neoplasm1ClinicalTrials
Neurofibroma, PlexiformD018318EFO:0000658plexiform neurofibroma2ClinicalTrials
Primary MyelofibrosisD055728EFO:0002430primary myelofibrosis3ClinicalTrials

Clinical Data

ClinicalTrials.gov PEGINTERFERON ALFA-2B
The Cochrane Collaboration PEGINTERFERON ALFA-2B

Biological Sequence

Description Sequence
Interferon alpha-2 precursor MALTFALLVALLVLSCKSSCSVGCDLPQTHSLGSRRTLMLLAQMRKISLFSCLKDRHDFG FPQEEFGNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEA CVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNL QESLRSKE

Compound Cross References

ATC L - ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L03 - IMMUNOSTIMULANTS
L03A - IMMUNOSTIMULANTS
L03AB - Interferons
L03AB10 - peginterferon alfa-2b

L - ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L03 - IMMUNOSTIMULANTS
L03A - IMMUNOSTIMULANTS
L03AB - Interferons
L03AB60 - peginterferon alfa-2b, combinations

ChemSpider ChemSpider Identifier not yet assigned
DailyMed peginterferon alfa-2b
Wikipedia Peginterferon_alfa-2b
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