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ChEMBL

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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1201560
CHEMBL1201560
Compound Name PEGINTERFERON ALFA-2A
ChEMBL Synonyms PEGASYS | RO 25-8310/000 | ROFERON-A | PEGINTERFERON ALFA-2A
Max Phase 4 (Approved)
Trade Names ROFERON-A | PEGASYS

Sources

  • Manually Added Drugs
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Molecule Features

CHEMBL1201560 compound icon
Drug Type:Oligopeptide Rule of Five:N First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:N Parenteral:Y Topical:N Black Box:Y Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Interferon alpha/beta receptor agonist Interferon alpha/beta receptor DailyMed PubMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
Depressive DisorderD003866EFO:0003761unipolar depression3ClinicalTrials
HIV InfectionsD015658EFO:0000764HIV infection2ClinicalTrials
InfectionD007239EFO:0000544infection3ClinicalTrials
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveD015464EFO:0000339chronic myelogenous leukemia3ClinicalTrials
Leukemia, Myeloid, AcuteD015470EFO:0000222acute myeloid leukemia1ClinicalTrials
Multiple MyelomaD009101EFO:0001378multiple myeloma2ClinicalTrials
NeoplasmsD009369EFO:0000311cancer1ClinicalTrials
NeoplasmsD009369EFO:0000616neoplasm1ClinicalTrials
Polycythemia VeraD011087EFO:0002429polycythemia vera3ClinicalTrials
Hepatitis DD003699EFO:0007304hepatitis D3ClinicalTrials
Thrombocythemia, EssentialD013920EFO:0000479essential thrombocythemia3ClinicalTrials
Breast NeoplasmsD001943EFO:0000305breast carcinoma2ClinicalTrials
Carcinoma, HepatocellularD006528EFO:0000182hepatocellular carcinoma2ClinicalTrials
Hepatitis B, ChronicD019694EFO:0004239chronic hepatitis B infection3ClinicalTrials
Leukemia, Lymphocytic, Chronic, B-CellD015451EFO:0000095chronic lymphocytic leukemia1ClinicalTrials
Primary MyelofibrosisD055728EFO:0002430primary myelofibrosis3ClinicalTrials
ThrombocytopeniaD013921HP:0001873thrombocytopenia2ClinicalTrials
Carcinoma, Renal CellD002292EFO:0002890renal carcinoma1ClinicalTrials
Hepatitis B, ChronicD019694EFO:0004197hepatitis B infection3ClinicalTrials
Hepatitis C, ChronicD019698EFO:0004220Chronic Hepatitis C infection4ClinicalTrials
DailyMed
MelanomaD008545EFO:0000756melanoma3ClinicalTrials
Hepatitis CD006526EFO:0003047hepatitis C infection3ClinicalTrials
LeukemiaD007938EFO:0000565leukemia2ClinicalTrials
Skin NeoplasmsD012878EFO:0004198skin neoplasm1ClinicalTrials
Hepatitis BD006509EFO:0004197hepatitis B infection4DailyMed

Clinical Data

ClinicalTrials.gov PEGINTERFERON ALFA-2A
The Cochrane Collaboration PEGINTERFERON ALFA-2A

Biological Sequence

Description Sequence
Interferon alpha-2 precursor MALTFALLVALLVLSCKSSCSVGCDLPQTHSLGSRRTLMLLAQMRKISLFSCLKDRHDFG FPQEEFGNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEA CVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNL QESLRSKE

Compound Cross References

ATC L - ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L03 - IMMUNOSTIMULANTS
L03A - IMMUNOSTIMULANTS
L03AB - Interferons
L03AB61 - peginterferon alfa-2a, combinations

L - ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L03 - IMMUNOSTIMULANTS
L03A - IMMUNOSTIMULANTS
L03AB - Interferons
L03AB11 - peginterferon alfa-2a

ChemSpider ChemSpider Identifier not yet assigned
DailyMed peginterferon alfa-2a
Wikipedia Peginterferon_alfa-2a
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