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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1201073
CHEMBL1201073
Compound Name SUCCIMER
ChEMBL Synonyms DMSA | Chemet | Dimercaptosuccinic Acid | Succimer | DIM-SA
Max Phase 4 (Approved)
Trade Names DMSA | Chemet | Dim-Sa | Dimercaptosuccinic Acid
Molecular Formula C4H6O4S2

Additional synonyms for CHEMBL1201073 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES OC(=O)[C@H](S)[C@H](S)C(=O)O
Standard InChI InChI=1S/C4H6O4S2/c5-3(6)1(9)2(10)4(7)8/h1-2,9-10H,(H,5,6)(H ...
Download InChI
Standard InChI Key ACTRVOBWPAIOHC-XIXRPRMCSA-N

Mechanism of Action

Mechanism of Action ChEMBL Target References
Lead chelating agent Lead FDA

Molecule Features

CHEMBL1201073 compound icon
Drug Type:Synthetic Small Molecule Rule of Five:Y First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:Y Parenteral:N Topical:N Black Box:N Availability Type:Prescription-only

Clinical Data

Number of clinical trials registered at clinicaltrials.gov
Number of reviews at The Cochrane Collaboration
Number of entries at British National Formulary

Structural Alerts

There are 7 structural alerts for CHEMBL1201073. To view alerts please click here.

Alternate Forms of Compound in ChEMBL


CHEMBL1201073

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Target Predictions

The two tables below display ChEMBL single-protein targets which are predicted to interact with CHEMBL1201073. A 1uM and 10 uM cut-off have been applied to ChEMBL bioactivity data used to generate the respective models and the yellow coloured rows correspond to genuine predictions, i.e. targets not included in the original training set for this compound.


1uM


ChEMBL_ID Target Name Organism Score
CHEMBL3369 Neprilysin Rattus norvegicus 0.999
CHEMBL1944 Neprilysin Homo sapiens 0.998
CHEMBL2625 Angiotensin-converting enzyme Rattus norvegicus 0.997
CHEMBL1808 Angiotensin-converting enzyme Homo sapiens 0.994
CHEMBL4074 Angiotensin-converting enzyme Oryctolagus cuniculus 0.994
CHEMBL3768 Neprilysin Oryctolagus cuniculus 0.989
CHEMBL4791 Endothelin-converting enzyme 1 Homo sapiens 0.959
CHEMBL3736 Angiotensin-converting enzyme 2 Homo sapiens 0.928
CHEMBL3439 Aminopeptidase A Homo sapiens 0.737
CHEMBL2590 Aminopeptidase N Sus scrofa 0.593



10uM


ChEMBL_ID Target Name Organism Score
CHEMBL3369 Neprilysin Rattus norvegicus 0.999
CHEMBL1944 Neprilysin Homo sapiens 0.996
CHEMBL2625 Angiotensin-converting enzyme Rattus norvegicus 0.996
CHEMBL1808 Angiotensin-converting enzyme Homo sapiens 0.995
CHEMBL4074 Angiotensin-converting enzyme Oryctolagus cuniculus 0.991
CHEMBL3768 Neprilysin Oryctolagus cuniculus 0.978
CHEMBL3736 Angiotensin-converting enzyme 2 Homo sapiens 0.899
CHEMBL4791 Endothelin-converting enzyme 1 Homo sapiens 0.894
CHEMBL3439 Aminopeptidase A Homo sapiens 0.887
CHEMBL2590 Aminopeptidase N Sus scrofa 0.873
CHEMBL2088 Carboxypeptidase A1 Homo sapiens 0.764

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
182.2 181.9708 0.28 3 152.19 ACID


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
6 4 0 4 2 0


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
2.74 - 1.05 -3.7 0 10 0.46

Compound Cross References

ChemSpider ChemSpider:ACTRVOBWPAIOHC-XIXRPRMCSA-N
DailyMed succimer
Wikipedia Dimercaptosuccinic_acid

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL1201073



ChEBI 63623
eMolecules 713371
FDA SRS DX1U2629QE
IBM Patent System C774F01CF3354689A180AD9A77A44C59
IBM Patents US7816398 US7351591 WO2007050565A2 US5519058 EP1879704A2 US20060030575 WO2010048191A1 WO2006014484A2 US7687106 US6576793 US6218446 US4218387 US6248870 US20020160433 US6667194 US20030078517 US20100303719 US20100041803 EP2170405A2 WO2009131786A2 WO2007142654A1 US7771727 US6306609 WO2005101000A2 US20090068168 US20030176670 US7598028 US20090312373 WO2008055112A2 US6610269 US20080074661 US20070246245 US20030170316 WO2004069281A1 WO1998052609A1 US6605142 US20100273328 WO2009005978A1 EP1931760A2 WO2001029235A2 EP1622602A2 US20020004065 US5885842 EP1176181B1 US20100166874 US20060024368 WO2002067880A1 WO2000040269A2 US7470779 US20020168327 US6121358 EP2139331A1 EP1806138A1 US7105701 US7691872 WO2007108947A2 WO2007008752A2 WO2007050077A1 WO2006073695A1 US6380356 US7037912 WO2000006639A1 EP1329225A2 US20040224012 EP1161487B1 US6509380 US5730968 EP2173327A2 US6919482 EP1372571A2 EP1409568B1 US20080066739 EP1866344A1 EP1021204A2 US5729813 EP0735441A1 US20100010178 WO2008127291A2 US7695719 US20040186080 US6024976 WO2003040222A2 EP1442751B1 US6420354 WO2002043806A2 US20100230644 US6838552 US20080086059 US20070104717 US5395876 EP2248895A2 US6638528 US20080081340 US20060035946 US5225182 US20050143386 US20050013836 WO2002036142A2 US5718941 US7211695
LINCS LSM-4749
MolPort MolPort-003-666-563
Nikkaji J193.712J
PubChem 2724354
PubChem: Thomson Pharma 16776628
SureChEMBL SCHEMBL14941

UniChem REST Service Call: https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/ACTRVOBWPAIOHC-XIXRPRMCSA-N spacer
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