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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1200790
CHEMBL1200790
Compound Name METHYPRYLON
ChEMBL Synonyms Methyprylon | Noludar
Max Phase 4 (Approved)
Trade Names Noludar
Molecular Formula C10H17NO2

Additional synonyms for CHEMBL1200790 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES CCC1(CC)C(=O)NCC(C)C1=O
Standard InChI InChI=1S/C10H17NO2/c1-4-10(5-2)8(12)7(3)6-11-9(10)13/h7H,4-6 ...
Download InChI
Standard InChI Key SIDLZWOQUZRBRU-UHFFFAOYSA-N

Mechanism of Action

Mechanism of Action ChEMBL Target References
GABA-A receptor; anion channel positive allosteric modulator GABA-A receptor; anion channel ISBN PubMed

Molecule Features

CHEMBL1200790 compound icon
Drug Type:Synthetic Small Molecule Rule of Five:Y First In Class:N Chirality:Racemic Mixture Prodrug:N Oral:Y Parenteral:N Topical:N Black Box:N Availability Type:Discontinued

Clinical Data

Number of clinical trials registered at clinicaltrials.gov
Number of reviews at The Cochrane Collaboration
Number of entries at British National Formulary

Structural Alerts

There are 2 structural alerts for CHEMBL1200790. To view alerts please click here.

Alternate Forms of Compound in ChEMBL


CHEMBL1200790

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Target Predictions

The two tables below display ChEMBL single-protein targets which are predicted to interact with CHEMBL1200790. A 1uM and 10 uM cut-off have been applied to ChEMBL bioactivity data used to generate the respective models and the yellow coloured rows correspond to genuine predictions, i.e. targets not included in the original training set for this compound.


10uM


ChEMBL_ID Target Name Organism Score
CHEMBL241 Phosphodiesterase 3A Homo sapiens 0.306
CHEMBL208 Progesterone receptor Homo sapiens 0.203

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
183.3 183.1259 1.47 2 46.17 NEUTRAL


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
2 1 0 3 1 0


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
12.11 - .65 .65 0 13 0.66

Compound Cross References

ATC N - NERVOUS SYSTEM
N05 - PSYCHOLEPTICS
N05C - HYPNOTICS AND SEDATIVES
N05CE - Piperidinedione derivatives
N05CE02 - methyprylon

ChemSpider ChemSpider:SIDLZWOQUZRBRU-UHFFFAOYSA-N
Wikipedia Methyprylon

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL1200790



ACToR 125-64-4
DrugBank DB01107
Guide to Pharmacology 7238
Human Metabolome Database HMDB15239
IBM Patent System DF0ED521574C6F242AFF084E4ADB5A0E
IBM Patents EP1842533A2 EP1658055A1 US20050186139 US20080274146 US20070003616 EP2131830A2 US20070183980 EP1742621B1 WO2007106550A2 WO2007028513A2 WO2005102294A2 EP1817011A2 WO2008107149A2 US20050191244 EP1845955A1 EP1928436A2 US20090004267 US20090005408 EP1765298A1 US20100260833 US20070231268 US20080152595 US20080317854 US20050236741 EP1658054B1 EP1515702A1 WO2006082097A1 US20100221322 US20050031546 EP1993519A2 WO2005102286A1 US3085932 US20060188447 EP1558221B1 US20060110327 EP1699440B1 EP1515702B1 US20070183979 US20060193782 WO2005102270A2 WO2003105808A1 US20100098758 EP1740161A2 EP1742621A2 US20080311049 WO2005016314A1 WO2006002883A1 US20080311197 EP1740156A1 US20070065365 EP1859789A1 US20050214223 US20060177380 EP1658055B1 US20050249792 WO2006058249A2
Nikkaji J82.012A J82.013J J41.174D
PubChem 4162
PubChem: Thomson Pharma 15195213
SureChEMBL SCHEMBL155838

UniChem REST Service Call: https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/SIDLZWOQUZRBRU-UHFFFAOYSA-N spacer
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