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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1200689
CHEMBL1200689
Compound Name NITRIC OXIDE
ChEMBL Synonyms NITRIC OXIDE | INOMAX
Max Phase 4 (Approved)
Trade Names INOMAX
Molecular Formula NO

Additional synonyms for CHEMBL1200689 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES O=[N]
Standard InChI InChI=1S/NO/c1-2
Standard InChI Key MWUXSHHQAYIFBG-UHFFFAOYSA-N

Sources

  • Orange Book
  • Scientific Literature
  • WHO Anatomical Therapeutic Chemical Classification

Alternate Forms of Compound in ChEMBL


CHEMBL1200689

Molecule Features

CHEMBL1200689 compound icon
Drug Type:Synthetic Small Molecule Rule of Five:Y First In Class:N Chirality:Achiral Molecule Prodrug:N Oral:N Parenteral:N Topical:Y Black Box:N Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Soluble guanylate cyclase activator Soluble guanylate cyclase DailyMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
Acute Kidney InjuryD058186HP:0001919Acute kidney injury3ClinicalTrials
AsthmaD001249EFO:0000270asthma2ClinicalTrials
Bronchopulmonary DysplasiaD001997Orphanet:70589Bronchopulmonary dysplasia3ClinicalTrials
HypertensionD006973EFO:0000537hypertension1ClinicalTrials
Myocardial InfarctionD009203EFO:0000612myocardial infarction2ClinicalTrials
Reperfusion InjuryD015427EFO:0002687ischemia reperfusion injury3ClinicalTrials
Wounds and InjuriesD014947EFO:0000546injury3ClinicalTrials
AnemiaD000740EFO:0004272anemia1ClinicalTrials
Cystic FibrosisD003550Orphanet:586Cystic fibrosis2ClinicalTrials
Death, Sudden, CardiacD016757EFO:0004278sudden cardiac arrest2ClinicalTrials
Hernias, Diaphragmatic, CongenitalD065630EFO:0005207congenital heart disease3ClinicalTrials
Opioid-Related DisordersD009293EFO:0005611opioid dependence2ClinicalTrials
Heart FailureD006333EFO:0000373congestive heart failure2ClinicalTrials
Leishmaniasis, CutaneousD016773EFO:0005046cutaneous Leishmaniasis3ClinicalTrials
StrokeD020521EFO:0000712stroke2ClinicalTrials
Urinary Tract InfectionsD014552EFO:0003103urinary tract infection1ClinicalTrials
Colorectal NeoplasmsD015179EFO:1001951colorectal carcinoma1ClinicalTrials
Coronary Artery DiseaseD003324EFO:0000378coronary artery disease2ClinicalTrials
Diabetic FootD017719EFO:1001459diabetic foot3ClinicalTrials
Gastroesophageal RefluxD005764EFO:0003948gastroesophageal reflux disease1ClinicalTrials
Lung DiseasesD008171EFO:0003818lung disease3ClinicalTrials
NeuralgiaD009437EFO:0005762neuropathic pain2ClinicalTrials
Pulmonary EmbolismD011655EFO:0003827pulmonary embolism2ClinicalTrials
Respiratory InsufficiencyD0121313ClinicalTrials
Skin UlcerD012883HP:0200042Skin ulcer2ClinicalTrials
Anemia, Sickle CellD000755Orphanet:232Sickle cell anemia2ClinicalTrials
BronchiolitisD001988HP:0011950Bronchiolitis3ClinicalTrials
Hypertension, PulmonaryD006976EFO:0001361pulmonary hypertension3ClinicalTrials
InflammationD007249MP:0001845inflammation2ClinicalTrials
Pressure UlcerD003668EFO:0007067decubitus ulcer1ClinicalTrials
Respiratory Distress Syndrome, AdultD012128EFO:1000637acute respiratory distress syndrome3ClinicalTrials
SepsisD018805HP:0100806sepsis3ClinicalTrials
Myocardial IschemiaD017202EFO:1001375Myocardial Ischemia2ClinicalTrials
Tinea PedisD014008EFO:0007512tinea pedis2ClinicalTrials
AlopeciaD000505Orphanet:79364Alopecia1ClinicalTrials
Brain IschemiaD002545HP:0002637Cerebral ischemia1ClinicalTrials
InfectionD007239EFO:0000544infection2ClinicalTrials
MalariaD008288EFO:0001068malaria2ClinicalTrials

Clinical Data

ClinicalTrials.gov NITRIC OXIDE
The Cochrane Collaboration NITRIC OXIDE

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
30 29.998 -0.45 0 39.37 -


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
1 0 0 2 0 0


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
- - - - 0 2 0.36

Structural Alerts

There are no structural alerts for CHEMBL1200689

Compound Cross References

ATC R - RESPIRATORY SYSTEM
R07 - OTHER RESPIRATORY SYSTEM PRODUCTS
R07A - OTHER RESPIRATORY SYSTEM PRODUCTS
R07AX - Other respiratory system products
R07AX01 - nitric oxide

ChemSpider ChemSpider:MWUXSHHQAYIFBG-UHFFFAOYSA-N
DailyMed nitric oxide
Wikipedia Nitric_oxide Nitroxyl

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL1200689



Brenda 662 39171 143641 277
ChEBI 16480
DrugBank DB00435
DrugCentral 1948
eMolecules 17497970
EPA CompTox Dashboard DTXSID1020938
Human Metabolome Database HMDB0003378
KEGG Ligand C00533
Metabolights MTBLC16480
Nikkaji J415.432K J1.313.254B
PharmGKB PA450635
PubChem 145068
PubChem: Thomson Pharma 15170299
Recon no
Rhea 16480
SureChEMBL SCHEMBL7560

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/MWUXSHHQAYIFBG-UHFFFAOYSA-N spacer
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