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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1200656
CHEMBL1200656
Compound Name NATAMYCIN
ChEMBL Synonyms NATAMYCIN | ANTIBIOTIC A-5283 | Myprozine | NATACYN | CL 12,625 | E235 | PIMARICIN | CL-12625
Max Phase 4 (Approved)
Trade Names Myprozine | Pimaricin | NATACYN
Molecular Formula C33H47NO13

Additional synonyms for CHEMBL1200656 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES C[C@@H]1C\C=C\C=C\C=C\C=C\[C@@H](C[C@@H]2O[C@](O)(C[C@@H](O) ...
Download SMILES
Standard InChI InChI=1S/C33H47NO13/c1-18-10-8-6-4-3-5-7-9-11-21(45-32-30(39 ...
Download InChI
Standard InChI Key NCXMLFZGDNKEPB-FFPOYIOWSA-N

Sources

  • British National Formulary
  • DrugMatrix
  • Orange Book
  • PubChem BioAssays
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Alternate Forms of Compound in ChEMBL


CHEMBL1200656

Molecule Features

CHEMBL1200656 compound icon
Drug Type:Natural Product-derived Rule of Five:N First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:N Parenteral:N Topical:Y Black Box:N Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Ergosterol sequestering agent Ergosterol PubMed PubMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
INFECTIOND007239EFO:0000544INFECTION4ATC

Clinical Data

ClinicalTrials.gov NATAMYCIN
The Cochrane Collaboration NATAMYCIN

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
665.7 665.3047 -2.82 3 230.98 ACID


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
14 7 3 14 8 2


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
3.71 8.12 .88 -1.7 0 47 0.15

Structural Alerts

There are 15 structural alerts for CHEMBL1200656. To view alerts please click here.

Compound Cross References

ATC A - ALIMENTARY TRACT AND METABOLISM
A07 - ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
A07A - INTESTINAL ANTIINFECTIVES
A07AA - Antibiotics
A07AA03 - natamycin

D - DERMATOLOGICALS
D01 - ANTIFUNGALS FOR DERMATOLOGICAL USE
D01A - ANTIFUNGALS FOR TOPICAL USE
D01AA - Antibiotics
D01AA02 - natamycin

A - ALIMENTARY TRACT AND METABOLISM
A01 - STOMATOLOGICAL PREPARATIONS
A01A - STOMATOLOGICAL PREPARATIONS
A01AB - Antiinfectives and antiseptics for local oral treatment
A01AB10 - natamycin

S - SENSORY ORGANS
S01 - OPHTHALMOLOGICALS
S01A - ANTIINFECTIVES
S01AA - Antibiotics
S01AA10 - natamycin

G - GENITO URINARY SYSTEM AND SEX HORMONES
G01 - GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
G01A - ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
G01AA - Antibiotics
G01AA02 - natamycin

ChemSpider ChemSpider:NCXMLFZGDNKEPB-FFPOYIOWSA-N
DailyMed natamycin
PubChem SID: 144204112
Wikipedia Natamycin

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL1200656



ACToR 7681-93-8
BindingDB 50370755
DrugBank DB00826
DrugCentral 1885
eMolecules 530975 29534936
EPA CompTox Dashboard DTXSID6021163
FDA SRS 8O0C852CPO
MolPort MolPort-003-939-127
PubChem 5284447
PubChem: Thomson Pharma 14937174 14839501
SureChEMBL SCHEMBL18140
ZINC ZINC000008220909

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/NCXMLFZGDNKEPB-FFPOYIOWSA-N spacer
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