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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL107367
CHEMBL107367
Compound Name FARGLITAZAR
ChEMBL Synonyms GI262570X | Farglitazar | GI262570
Max Phase 2
Trade Names
Molecular Formula C34H30N2O5

Additional synonyms for CHEMBL107367 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES Cc1oc(nc1CCOc2ccc(C[C@H](Nc3ccccc3C(=O)c4ccccc4)C(=O)O)cc2)c ...
Download SMILES
Standard InChI InChI=1S/C34H30N2O5/c1-23-29(36-33(41-23)26-12-6-3-7-13-26)2 ...
Download InChI
Standard InChI Key ZZCHHVUQYRMYLW-HKBQPEDESA-N

Sources

  • AstraZeneca Deposited Data
  • Clinical Candidates
  • PubChem BioAssays
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names

Alternate Forms of Compound in ChEMBL


CHEMBL107367

Molecule Features

CHEMBL107367 compound icon
Drug Type:Synthetic Small Molecule Rule of Five:N First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:Unclassified Parenteral:Unclassified Topical:Unclassified Black Box:Unclassified Availability Type:Unclassified

Mechanism of Action

Mechanism of Action ChEMBL Target References
Peroxisome proliferator-activated receptor gamma agonist Peroxisome proliferator-activated receptor gamma PubMed

Clinical Data

ClinicalTrials.gov FARGLITAZAR
The Cochrane Collaboration FARGLITAZAR

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Target Predictions

The two tables below display ChEMBL single-protein targets which are predicted to interact with CHEMBL107367. A 1uM and 10 uM cut-off have been applied to ChEMBL bioactivity data used to generate the respective models and the yellow coloured rows correspond to genuine predictions, i.e. targets not included in the original training set for this compound.


1uM


ChEMBL_ID Target Name Organism Score
CHEMBL239 Peroxisome proliferator-activated receptor alpha Homo sapiens 1.000
CHEMBL235 Peroxisome proliferator-activated receptor gamma Homo sapiens 1.000
CHEMBL2459 Peroxisome proliferator-activated receptor gamma Mus musculus 1.000
CHEMBL2128 Peroxisome proliferator-activated receptor alpha Mus musculus 1.000
CHEMBL3979 Peroxisome proliferator-activated receptor delta Homo sapiens 0.538

10uM


ChEMBL_ID Target Name Organism Score
CHEMBL239 Peroxisome proliferator-activated receptor alpha Homo sapiens 1.000
CHEMBL235 Peroxisome proliferator-activated receptor gamma Homo sapiens 1.000
CHEMBL2128 Peroxisome proliferator-activated receptor alpha Mus musculus 1.000
CHEMBL3979 Peroxisome proliferator-activated receptor delta Homo sapiens 1.000
CHEMBL2459 Peroxisome proliferator-activated receptor gamma Mus musculus 1.000
CHEMBL335 Protein-tyrosine phosphatase 1B Homo sapiens 0.996

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
546.6 546.2155 6.56 12 101.66 ACID


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
6 2 2 7 2 1


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
3.91 1.35 5.46 2.06 5 41 0.17

Structural Alerts

There are 1 structural alerts for CHEMBL107367. To view alerts please click here.

Compound Cross References

ChemSpider ChemSpider:ZZCHHVUQYRMYLW-HKBQPEDESA-N
PubChem SID: 144210538
Wikipedia Farglitazar

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL107367



ACToR 196808-45-4
BindingDB 50085044
EPA CompTox Dashboard DTXSID1047310
FDA SRS 3433GY7132
Guide to Pharmacology 2672
IBM Patent System 1A84F958CE478B11C667D03344728036
Nikkaji J1.046.637G
PDBe 570
PubChem 170364
PubChem: Drugs of the Future 12015156
PubChem: Thomson Pharma 14788110 14788109
SureChEMBL SCHEMBL501024
ZINC ZINC000049639808

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/ZZCHHVUQYRMYLW-HKBQPEDESA-N spacer
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