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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1201037
CHEMBL1201037
Compound Name EFLORNITHINE HYDROCHLORIDE
ChEMBL Synonyms Vaniqa | Ornidyl | Dfmo Hcl | Difluromethylornithine | Eflornithine | Eflornithine HCl | MDL-71782A
Max Phase 4 (Approved)
Trade Names Vaniqa | Ornidyl
Molecular Formula C6H15ClF2N2O3

Additional synonyms for CHEMBL1201037 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES O.Cl.NCCCC(N)(C(F)F)C(=O)O
Standard InChI InChI=1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h ...
Download InChI
Standard InChI Key FJPAMFNRCFEGSD-UHFFFAOYSA-N

Mechanism of Action

Mechanism of Action ChEMBL Target References
Ornithine decarboxylase inhibitor Ornithine decarboxylase DailyMed

Molecule Features

CHEMBL1201037 compound icon
Drug Type:Synthetic Small Molecule Rule of Five:Y First In Class:N Chirality:Racemic Mixture Prodrug:N Oral:N Parenteral:Y Topical:Y Black Box:N Availability Type:Prescription-only

Clinical Trials for Compound

Number of clinical trials registered at clinicaltrials.gov

Alternate Forms of Compound in ChEMBL


CHEMBL1201037

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Ro5 Violations #Rotatable Bonds Ro3 Med Chem Friendly Molecular Species
182.2 182.0867 -3.22 0 5 No Yes ZWITTERION


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms Num Alerts QED Weighted
1.22 10.45 .09 -2.46 0 12 0 0.42

Compound Cross References

ChemSpider ChemSpider:FJPAMFNRCFEGSD-UHFFFAOYSA-N
DailyMed eflornithine hydrochloride

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL1201037



PubChem: Drugs of the Future 12012626
eMolecules 29550700
PubChem: Thomson Pharma 14847342
PubChem 441361

UniChem REST Service Call: https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/FJPAMFNRCFEGSD-UHFFFAOYSA-N spacer
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