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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6166
Target Type SINGLE PROTEIN
Preferred Name Mitogen-activated protein kinase kinase kinase kinase 4
Synonyms HGK | HPK/GCK-like kinase HGK | KIAA0687 | MAP4K4 | MAPK/ERK kinase kinase kinase 4 | MEK kinase kinase 4 | MEKKK 4 | Mitogen-activated protein kinase kinase kinase kinase 4 | NIK | Nck-interacting kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase msn subfamily

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase kinase kinase kinase 4 SINGLE PROTEIN O95819

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000071054
Ensembl ENSG00000071054
GO Cellular Component GO:0005737 (cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004111 (creatine kinase activity)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004702 (receptor signaling protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0016310 (phosphorylation)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0030033 (microvillus assembly)
GO:0035556 (intracellular signal transduction)
GO:0043066 (negative regulation of apoptotic process)
GO:0046328 (regulation of JNK cascade)
Wikipedia MAP4K4

Target Cross References - Protein

canSAR O95819
Human Protein Atlas ENSG00000071054
IntAct O95819
Guide to Pharmacology 2088
Open Targets ENSG00000071054
PharmGKB PA30612
Pharos O95819 (Tchem)
Reactome R-HSA-2559580 (Oxidative Stress Induced Senescence.)
UniProt O75172 O95819 Q9NST7

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001180 (CNH_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
PF00780 (CNH)

Target Cross References - Structure

PDBe 4OBO 4OBP 4OBQ 4RVT 4U3Y 4U3Z 4U40 4U41 4U42 4U43 4U44 4U45 4ZK5 4ZP5 5DI1
CREDO 4OBO 4OBP 4OBQ 4RVT 4U3Y 4U3Z 4U40 4U41 4U42 4U43 4U44 4U45 4ZK5 4ZP5 5DI1
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