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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6110
Target Type SINGLE PROTEIN
Preferred Name Thioredoxin glutathione reductase
Synonyms TGR | Thioredoxin glutathione reductase
Organism Schistosoma mansoni
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Thioredoxin glutathione reductase SINGLE PROTEIN Q962Y6

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005623 (cell)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004791 (thioredoxin-disulfide reductase activity)
GO:0009055 (electron carrier activity)
GO:0015035 (protein disulfide oxidoreductase activity)
GO:0016491 (oxidoreductase activity)
GO:0016668 (oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor)
GO:0046872 (metal ion binding)
GO:0050660 (flavin adenine dinucleotide binding)
GO Biological Process GO:0022900 (electron transport chain)
GO:0045454 (cell redox homeostasis)
GO:0055114 (oxidation-reduction process)
GO:0098869 (cellular oxidant detoxification)

Target Cross References - Protein

UniProt Q962Y6

Target Cross References - Domain

InterPro IPR001100 (Pyr_nuc-diS_OxRdtase.)
IPR002109 (Glutaredoxin.)
IPR004099 (Pyr_nucl-diS_OxRdtase_dimer.)
IPR006338 (Thioredoxin/glutathione_Rdtase.)
IPR011767 (GLR_AS.)
IPR011899 (Glutaredoxin_euk/vir.)
IPR012999 (Pyr_OxRdtase_I_AS.)
IPR016156 (FAD/NAD-linked_Rdtase_dimer_sf.)
IPR023753 (FAD/NAD-binding_dom.)
IPR036188 (FAD/NAD-bd_sf.)
IPR036249 (Thioredoxin-like_sf.)
Pfam PF00462 (Glutaredoxin)
PF02852 (Pyr_redox_dim)
PF07992 (Pyr_redox_2)

Target Cross References - Structure

PDBe 2V6O 2X8C 2X8G 2X8H 2X99 3H4K
CREDO 2V6O 2X8C 2X8G 2X8H 2X99 3H4K
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