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Target Report Card

Target Name and Classification

Target ID CHEMBL5990
Preferred Name Breast cancer type 1 susceptibility protein
Synonyms BRCA1 | Breast cancer type 1 susceptibility protein | RING finger protein 53 | RING-type E3 ubiquitin transferase BRCA1 | RNF53
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Breast cancer type 1 susceptibility protein SINGLE PROTEIN P38398

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000012048
Ensembl ENSG00000012048
GO Cellular Component GO:0000151 (ubiquitin ligase complex)
GO:0000793 (condensed chromosome)
GO:0000794 (condensed nuclear chromosome)
GO:0000800 (lateral element)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005694 (chromosome)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0008274 (gamma-tubulin ring complex)
GO:0031436 (BRCA1-BARD1 complex)
GO:0032991 (macromolecular complex)
GO:0070531 (BRCA1-A complex)
GO Molecular Function GO:0001105 (RNA polymerase II transcription coactivator activity)
GO:0003677 (DNA binding)
GO:0003684 (damaged DNA binding)
GO:0003713 (transcription coactivator activity)
GO:0003723 (RNA binding)
GO:0004842 (ubiquitin-protein transferase activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0015631 (tubulin binding)
GO:0016740 (transferase activity)
GO:0019899 (enzyme binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046872 (metal ion binding)
GO:0050681 (androgen receptor binding)
GO:0070063 (RNA polymerase binding)
GO Biological Process GO:0000724 (double-strand break repair via homologous recombination)
GO:0000729 (DNA double-strand break processing)
GO:0000731 (DNA synthesis involved in DNA repair)
GO:0000732 (strand displacement)
GO:0006260 (DNA replication)
GO:0006281 (DNA repair)
GO:0006301 (postreplication repair)
GO:0006302 (double-strand break repair)
GO:0006303 (double-strand break repair via nonhomologous end joining)
GO:0006310 (DNA recombination)
GO:0006349 (regulation of gene expression by genetic imprinting)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006359 (regulation of transcription from RNA polymerase III promoter)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006915 (apoptotic process)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0006978 (DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)
GO:0007049 (cell cycle)
GO:0007059 (chromosome segregation)
GO:0007098 (centrosome cycle)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0009048 (dosage compensation by inactivation of X chromosome)
GO:0010212 (response to ionizing radiation)
GO:0010575 (positive regulation of vascular endothelial growth factor production)
GO:0010628 (positive regulation of gene expression)
GO:0016567 (protein ubiquitination)
GO:0016579 (protein deubiquitination)
GO:0030521 (androgen receptor signaling pathway)
GO:0031398 (positive regulation of protein ubiquitination)
GO:0033147 (negative regulation of intracellular estrogen receptor signaling pathway)
GO:0035066 (positive regulation of histone acetylation)
GO:0035067 (negative regulation of histone acetylation)
GO:0042127 (regulation of cell proliferation)
GO:0042981 (regulation of apoptotic process)
GO:0043009 (chordate embryonic development)
GO:0043627 (response to estrogen)
GO:0044030 (regulation of DNA methylation)
GO:0044818 (mitotic G2/M transition checkpoint)
GO:0045717 (negative regulation of fatty acid biosynthetic process)
GO:0045739 (positive regulation of DNA repair)
GO:0045766 (positive regulation of angiogenesis)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046600 (negative regulation of centriole replication)
GO:0051571 (positive regulation of histone H3-K4 methylation)
GO:0051572 (negative regulation of histone H3-K4 methylation)
GO:0051573 (negative regulation of histone H3-K9 methylation)
GO:0051574 (positive regulation of histone H3-K9 methylation)
GO:0051865 (protein autoubiquitination)
GO:0070317 (negative regulation of G0 to G1 transition)
GO:0070512 (positive regulation of histone H4-K20 methylation)
GO:0071158 (positive regulation of cell cycle arrest)
GO:0071356 (cellular response to tumor necrosis factor)
GO:0071681 (cellular response to indole-3-methanol)
GO:0072425 (signal transduction involved in G2 DNA damage checkpoint)
GO:0085020 (protein K6-linked ubiquitination)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:1902042 (negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)
GO:2000378 (negative regulation of reactive oxygen species metabolic process)
GO:2000617 (positive regulation of histone H3-K9 acetylation)
GO:2000620 (positive regulation of histone H4-K16 acetylation)
Wikipedia BRCA1

Target Cross References - Protein

canSAR P38398
CGD Breast-ovarian cancer, familial, susceptibility to, 1; Pancreatic cancer, susceptibility to
Human Protein Atlas ENSG00000012048
IntAct P38398
Open Targets ENSG00000012048
PharmGKB PA25411
Reactome R-HSA-1221632 (Meiotic synapsis.)
R-HSA-3108214 (SUMOylation of DNA damage response and repair proteins.)
R-HSA-5685938 (HDR through Single Strand Annealing (SSA).)
R-HSA-5685942 (HDR through Homologous Recombination (HRR).)
R-HSA-5689901 (Metalloprotease DUBs.)
R-HSA-5693554 (Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA).)
R-HSA-5693565 (Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.)
R-HSA-5693568 (Resolution of D-loop Structures through Holliday Junction Intermediates.)
R-HSA-5693571 (Nonhomologous End-Joining (NHEJ).)
R-HSA-5693579 (Homologous DNA Pairing and Strand Exchange.)
R-HSA-5693607 (Processing of DNA double-strand break ends.)
R-HSA-5693616 (Presynaptic phase of homologous DNA pairing and strand exchange.)
R-HSA-6796648 (TP53 Regulates Transcription of DNA Repair Genes.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
R-HSA-69473 (G2/M DNA damage checkpoint.)
R-HSA-8953750 (Transcriptional Regulation by E2F6.)
R-HSA-912446 (Meiotic recombination.)
UniProt E9PFZ0 O15129 P38398 Q1RMC1 Q3LRJ0 Q3LRJ6 Q6IN79 Q7KYU9

Target Cross References - Domain

InterPro IPR001357 (BRCT_dom.)
IPR001841 (Znf_RING.)
IPR011364 (BRCA1.)
IPR013083 (Znf_RING/FYVE/PHD.)
IPR017907 (Znf_RING_CS.)
IPR018957 (Znf_C3HC4_RING-type.)
IPR025994 (BRCA1_serine_dom.)
IPR031099 (BRCA1-associated.)
IPR036420 (BRCT_dom_sf.)
Pfam PF00097 (zf-C3HC4)
PF00533 (BRCT)
PF12820 (BRCT_assoc)

Target Cross References - Structure

PDBe 1JNX 1N5O 1T15 1T29 1T2U 1T2V 1Y98 2ING 3COJ 3K0H 3K0K 3K15 3K16 3PXA 3PXB 3PXC 3PXD 3PXE 4IFI 4IGK 4JLU 4OFB 4U4A 4Y18 More...
CREDO 1JNX 1N5O 1T15 1T29 1T2U 1T2V 1Y98 2ING 3COJ 3K0H 3K0K 3K15 3K16 3PXA 3PXB 3PXC 3PXD 3PXE 4IFI 4IGK 4JLU 4OFB 4U4A 4Y18 More...