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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5936
Target Type SINGLE PROTEIN
Preferred Name Toll-like receptor 7
Synonyms TLR7 | Toll-like receptor 7
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > toll-like and il-1 receptors

Target Components

Component Description Relationship Accession
Toll-like receptor 7 SINGLE PROTEIN Q9NYK1

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3137288 TLR7 and TLR8 PROTEIN FAMILY
CHEMBL2111471 Toll-like receptor (TLR7/TLR9) PROTEIN FAMILY

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1690 HYDROXYCHLOROQUINE SULFATE Toll-like receptor 7 antagonist DailyMed PubMed PubMed
CHEMBL1282 IMIQUIMOD Toll-like receptor 7 agonist FDA PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196664
Ensembl ENSG00000196664
GO Cellular Component GO:0005764 (lysosome)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0010008 (endosome membrane)
GO:0016021 (integral to membrane)
GO:0032009 (early phagosome)
GO Molecular Function GO:0003725 (double-stranded RNA binding)
GO:0003727 (single-stranded RNA binding)
GO:0004888 (transmembrane receptor activity)
GO:0035197 (siRNA binding)
GO Biological Process GO:0006954 (inflammatory response)
GO:0007252 (I-kappaB phosphorylation)
GO:0032722 (positive regulation of chemokine production)
GO:0032757 (positive regulation of interleukin-8 production)
GO:0042346 (positive regulation of NF-kappaB import into nucleus)
GO:0045078 (positive regulation of interferon-gamma biosynthetic process)
GO:0045087 (innate immune response)
GO:0045356 (positive regulation of interferon-alpha biosynthetic process)
GO:0045359 (positive regulation of interferon-beta biosynthetic process)
GO:0045416 (positive regulation of interleukin-8 biosynthetic process)
GO:0051607 (defense response to virus)
GO:0071260 (cellular response to mechanical stimulus)
Wikipedia TLR_7

Target Cross References - Protein

canSAR Q9NYK1
Human Protein Atlas ENSG00000196664
IntAct Q9NYK1
Guide to Pharmacology 1757 (TLR7)
PharmGKB PA38008
Reactome REACT_6900 (Signaling in Immune system.)
UniProt Q9NR98 Q9NYK1

Target Cross References - Domain

InterPro IPR000157 (Toll-Interleukin_rcpt.)
IPR000372 (LRR-contain_N.)
IPR000483 (Cys-rich_flank_reg_C.)
IPR001611 (Leu-rich_rpt.)
IPR003591 (Leu-rich_rpt_typical-subtyp.)
Pfam PF00560 (LRR_1)
PF01582 (TIR)
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