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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5913
Preferred Name Leptin receptor
Synonyms CD_antigen=CD295 | DB | HuB219 | LEP-R | LEPR | Leptin receptor | OB receptor | OB-R | OBR
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Leptin receptor SINGLE PROTEIN P48357

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2107857 METRELEPTIN Leptin receptor agonist 4 FDA

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000116678
Ensembl ENSG00000116678
GO Cellular Component GO:0005576 (extracellular region)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0004888 (transmembrane signaling receptor activity)
GO:0004896 (cytokine receptor activity)
GO:0005515 (protein binding)
GO:0038021 (leptin receptor activity)
GO:0042802 (identical protein binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0006112 (energy reserve metabolic process)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007275 (multicellular organism development)
GO:0008203 (cholesterol metabolic process)
GO:0010507 (negative regulation of autophagy)
GO:0019953 (sexual reproduction)
GO:0030217 (T cell differentiation)
GO:0033210 (leptin-mediated signaling pathway)
GO:0042593 (glucose homeostasis)
GO:0044321 (response to leptin)
GO:0045721 (negative regulation of gluconeogenesis)
GO:0046850 (regulation of bone remodeling)
GO:0051346 (negative regulation of hydrolase activity)
GO:0060259 (regulation of feeding behavior)
GO:0097009 (energy homeostasis)
GO:0098868 (bone growth)
GO:2000505 (regulation of energy homeostasis)
Wikipedia Leptin_receptor

Target Cross References - Protein

canSAR P48357
CGD Obesity, morbid, with hypogonadism
Human Protein Atlas ENSG00000116678
IntAct P48357
Open Targets ENSG00000116678
PharmGKB PA229
Reactome R-HSA-2586552 (Signaling by Leptin.)
UniProt P48357 Q13592 Q13593 Q13594 Q92919 Q92920 Q92921

Target Cross References - Domain

InterPro IPR003529 (Hematopoietin_rcpt_Gp130_CS.)
IPR003531 (Hempt_rcpt_S_F1_CS.)
IPR003961 (FN3_dom.)
IPR007110 (Ig-like_dom.)
IPR010457 (IgC2-like_lig-bd.)
IPR013783 (Ig-like_fold.)
IPR015752 (Lep_receptor.)
Pfam PF06328 (Lep_receptor_Ig)

Target Cross References - Structure