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Target Report Card

Target Name and Classification

Target ID CHEMBL5868
Preferred Name Nuclear receptor ROR-alpha
Synonyms NR1F1 | Nuclear receptor ROR-alpha | Nuclear receptor RZR-alpha | Nuclear receptor subfamily 1 group F member 1 | RAR-related orphan receptor A | RORA | RZRA | Retinoid-related orphan receptor-alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 1 > nuclear hormone receptor subfamily 1 group f > nuclear hormone receptor subfamily 1 group f member 1

Target Components

Component Description Relationship Accession
Nuclear receptor ROR-alpha SINGLE PROTEIN P35398

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000069667
Ensembl ENSG00000069667
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0001046 (core promoter sequence-specific DNA binding)
GO:0001222 (transcription corepressor binding)
GO:0001223 (transcription coactivator binding)
GO:0001228 (transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008013 (beta-catenin binding)
GO:0008134 (transcription factor binding)
GO:0008142 (oxysterol binding)
GO:0008270 (zinc ion binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO:0098531 (transcription factor activity, direct ligand regulated sequence-specific DNA binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006805 (xenobiotic metabolic process)
GO:0006809 (nitric oxide biosynthetic process)
GO:0007623 (circadian rhythm)
GO:0008589 (regulation of smoothened signaling pathway)
GO:0010575 (positive regulation of vascular endothelial growth factor production)
GO:0010906 (regulation of glucose metabolic process)
GO:0019218 (regulation of steroid metabolic process)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0021702 (cerebellar Purkinje cell differentiation)
GO:0021930 (cerebellar granule cell precursor proliferation)
GO:0030522 (intracellular receptor signaling pathway)
GO:0032922 (circadian regulation of gene expression)
GO:0036315 (cellular response to sterol)
GO:0042632 (cholesterol homeostasis)
GO:0042692 (muscle cell differentiation)
GO:0042752 (regulation of circadian rhythm)
GO:0042753 (positive regulation of circadian rhythm)
GO:0043030 (regulation of macrophage activation)
GO:0043124 (negative regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045599 (negative regulation of fat cell differentiation)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046068 (cGMP metabolic process)
GO:0048511 (rhythmic process)
GO:0050728 (negative regulation of inflammatory response)
GO:0060850 (regulation of transcription involved in cell fate commitment)
GO:0070328 (triglyceride homeostasis)
GO:0071347 (cellular response to interleukin-1)
GO:0071356 (cellular response to tumor necrosis factor)
GO:0071456 (cellular response to hypoxia)
GO:0072539 (T-helper 17 cell differentiation)
Wikipedia RAR-related_orphan_receptor_alpha

Target Cross References - Protein

canSAR P35398
Human Protein Atlas ENSG00000069667
IntAct P35398
Guide to Pharmacology 598
Open Targets ENSG00000069667
PharmGKB PA34630
Pharos P35398 (Tchem)
Reactome R-HSA-1368082 (RORA activates gene expression.)
R-HSA-1368108 (BMAL1:CLOCK,NPAS2 activates circadian gene expression.)
R-HSA-1989781 (PPARA activates gene expression.)
R-HSA-383280 (Nuclear Receptor transcription pathway.)
R-HSA-400253 (Circadian Clock.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
UniProt P35397 P35398 P35399 P45445 Q495X4 Q96H83

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR003079 (ROR_rcpt.)
IPR013088 (Znf_NHR/GATA.)
IPR035500 (NHR_like_dom_sf.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 1N83 1S0X 4S15
CREDO 1N83 1S0X 4S15