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Target Report Card

Target Name and Classification

Target ID CHEMBL5804
Preferred Name Toll-like receptor 9
Synonyms CD_antigen=CD289 | TLR9 | Toll-like receptor 9
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > toll-like and il-1 receptors

Target Components

Component Description Relationship Accession
Toll-like receptor 9 SINGLE PROTEIN Q9NR96

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111471 Toll-like receptor (TLR7/TLR9) PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1690 HYDROXYCHLOROQUINE SULFATE Toll-like receptor 9 antagonist 4 FDA PubMed PubMed
CHEMBL2103793 AGATOLIMOD SODIUM Toll-like receptor 9 agonist 3 Other PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000239732
Ensembl ENSG00000239732
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005764 (lysosome)
GO:0005768 (endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0010008 (endosome membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0016324 (apical plasma membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0032009 (early phagosome)
GO:0036020 (endolysosome membrane)
GO:0045335 (phagocytic vesicle)
GO Molecular Function GO:0004888 (transmembrane signaling receptor activity)
GO:0005149 (interleukin-1 receptor binding)
GO:0016303 (1-phosphatidylinositol-3-kinase activity)
GO:0035197 (siRNA binding)
GO:0042803 (protein homodimerization activity)
GO:0045322 (unmethylated CpG binding)
GO Biological Process GO:0002224 (toll-like receptor signaling pathway)
GO:0002237 (response to molecule of bacterial origin)
GO:0002376 (immune system process)
GO:0002639 (positive regulation of immunoglobulin production)
GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007252 (I-kappaB phosphorylation)
GO:0007409 (axonogenesis)
GO:0010628 (positive regulation of gene expression)
GO:0030277 (maintenance of gastrointestinal epithelium)
GO:0030890 (positive regulation of B cell proliferation)
GO:0032088 (negative regulation of NF-kappaB transcription factor activity)
GO:0032640 (tumor necrosis factor production)
GO:0032715 (negative regulation of interleukin-6 production)
GO:0032717 (negative regulation of interleukin-8 production)
GO:0032722 (positive regulation of chemokine production)
GO:0032725 (positive regulation of granulocyte macrophage colony-stimulating factor production)
GO:0032728 (positive regulation of interferon-beta production)
GO:0032733 (positive regulation of interleukin-10 production)
GO:0032735 (positive regulation of interleukin-12 production)
GO:0032741 (positive regulation of interleukin-18 production)
GO:0032755 (positive regulation of interleukin-6 production)
GO:0032757 (positive regulation of interleukin-8 production)
GO:0032760 (positive regulation of tumor necrosis factor production)
GO:0034122 (negative regulation of toll-like receptor signaling pathway)
GO:0034123 (positive regulation of toll-like receptor signaling pathway)
GO:0034162 (toll-like receptor 9 signaling pathway)
GO:0034163 (regulation of toll-like receptor 9 signaling pathway)
GO:0036092 (phosphatidylinositol-3-phosphate biosynthetic process)
GO:0042742 (defense response to bacterium)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043410 (positive regulation of MAPK cascade)
GO:0043507 (positive regulation of JUN kinase activity)
GO:0045078 (positive regulation of interferon-gamma biosynthetic process)
GO:0045087 (innate immune response)
GO:0045356 (positive regulation of interferon-alpha biosynthetic process)
GO:0045359 (positive regulation of interferon-beta biosynthetic process)
GO:0045577 (regulation of B cell differentiation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046330 (positive regulation of JNK cascade)
GO:0050707 (regulation of cytokine secretion)
GO:0050729 (positive regulation of inflammatory response)
GO:0050829 (defense response to Gram-negative bacterium)
GO:0050871 (positive regulation of B cell activation)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051770 (positive regulation of nitric-oxide synthase biosynthetic process)
GO:1901224 (positive regulation of NIK/NF-kappaB signaling)
GO:1901895 (negative regulation of calcium-transporting ATPase activity)
Wikipedia TLR9

Target Cross References - Protein

canSAR Q9NR96
Human Protein Atlas ENSG00000239732
IntAct Q9NR96
Guide to Pharmacology 1759
Open Targets ENSG00000239732
PharmGKB PA38010
Reactome R-HSA-109704 (PI3K Cascade.)
R-HSA-1679131 (Trafficking and processing of endosomal TLR.)
R-HSA-168138 (Toll Like Receptor 9 (TLR9) Cascade.)
R-HSA-975110 (TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.)
R-HSA-975138 (TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.)
R-HSA-975155 (MyD88 dependent cascade initiated on endosome.)
UniProt B3Y661 D1CS56 Q6UVZ2 Q9HD68 Q9HD69 Q9HD70 Q9NR96 Q9NYC2 Q9NYC3

Target Cross References - Domain

InterPro IPR000157 (TIR_dom.)
IPR001611 (Leu-rich_rpt.)
IPR003591 (Leu-rich_rpt_typical-subtyp.)
IPR027181 (TLR9.)
IPR035897 (Toll_tir_struct_dom_sf.)
Pfam PF01582 (TIR)
PF13516 (LRR_6)
PF13855 (LRR_8)