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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5701
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase TAO3
Synonyms CTCL-associated antigen HD-CL-09 | Cutaneous T-cell lymphoma-associated antigen HD-CL-09 | DPK | Dendritic cell-derived protein kinase | JIK | JNK/SAPK-inhibitory kinase | Jun kinase-inhibitory kinase | KDS | Kinase from chicken homolog A | MAP3K18 | Serine/threonine-protein kinase TAO3 | TAOK3 | Thousand and one amino acid protein 3 | hKFC-A
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase tao subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase TAO3 SINGLE PROTEIN Q9H2K8

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000135090
Ensembl ENSG00000135090
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004709 (MAP kinase kinase kinase activity)
GO:0004860 (protein kinase inhibitor activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000186 (activation of MAPKK activity)
GO:0006281 (DNA repair)
GO:0006468 (protein phosphorylation)
GO:0006469 (negative regulation of protein kinase activity)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0007095 (mitotic G2 DNA damage checkpoint)
GO:0007399 (nervous system development)
GO:0016310 (phosphorylation)
GO:0032874 (positive regulation of stress-activated MAPK cascade)
GO:0042981 (regulation of apoptotic process)
GO:0043507 (positive regulation of JUN kinase activity)
GO:0046329 (negative regulation of JNK cascade)
GO:0046330 (positive regulation of JNK cascade)
GO:0046777 (protein autophosphorylation)
Wikipedia TAOK3

Target Cross References - Protein

canSAR Q9H2K8
Human Protein Atlas ENSG00000135090
IntAct Q9H2K8
Guide to Pharmacology 2235
Open Targets ENSG00000135090
PharmGKB PA134975064
Pharos Q9H2K8 (Tbio)
UniProt Q658N1 Q8IUM4 Q9H2K8 Q9HC79 Q9NZM9 Q9UHG7

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
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