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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5689
Target Type SINGLE PROTEIN
Preferred Name Tryptophan 5-hydroxylase 1
Synonyms TPH | TPH1 | TPRH | TRPH | Tryptophan 5-hydroxylase 1 | Tryptophan 5-monooxygenase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Tryptophan 5-hydroxylase 1 SINGLE PROTEIN P17752

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3831287 Tryptophan 5-hydroxylase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000129167
Ensembl ENSG00000129167
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0043005 (neuron projection)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0004510 (tryptophan 5-monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0016491 (oxidoreductase activity)
GO:0016714 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen)
GO:0046872 (metal ion binding)
GO Biological Process GO:0007623 (circadian rhythm)
GO:0009072 (aromatic amino acid family metabolic process)
GO:0030279 (negative regulation of ossification)
GO:0035902 (response to immobilization stress)
GO:0042427 (serotonin biosynthetic process)
GO:0045600 (positive regulation of fat cell differentiation)
GO:0046219 (indolalkylamine biosynthetic process)
GO:0046849 (bone remodeling)
GO:0055114 (oxidation-reduction process)
GO:0060749 (mammary gland alveolus development)
Wikipedia TPH1

Target Cross References - Protein

canSAR P17752
Human Protein Atlas ENSG00000129167
IntAct P17752
Open Targets ENSG00000129167
PharmGKB PA355
Reactome R-HSA-209931 (Serotonin and melatonin biosynthesis.)
UniProt D3DQX6 O95188 O95189 P17752 Q16736 Q3KPG8

Target Cross References - Domain

InterPro IPR001273 (ArAA_hydroxylase.)
IPR002912 (ACT_dom.)
IPR005963 (Trp_5_mOase.)
IPR018301 (ArAA_hydroxylase_Fe/CU_BS.)
IPR019773 (Tyrosine_3-monooxygenase-like.)
IPR019774 (Aromatic-AA_hydroxylase_C.)
IPR036329 (Aro-AA_hydroxylase_C_sf.)
IPR036951 (ArAA_hydroxylase_sf.)
Pfam PF00351 (Biopterin_H)

Target Cross References - Structure

PDBe 1MLW 3HF6 3HF8 3HFB 5J6D 5L01 5TPG
CREDO 1MLW 3HF6 3HF8 3HFB 5J6D 5L01 5TPG
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