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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5508
Target Type SINGLE PROTEIN
Preferred Name Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Synonyms Dual specificity YAK1-related kinase | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Dyrk | Dyrk1a | MNBH | Protein kinase minibrain homolog | RP86
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Dual specificity tyrosine-phosphorylation-regulated kinase 1A SINGLE PROTEIN Q63470

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005730 (nucleolus)
GO:0016607 (nuclear speck)
GO:0030529 (intracellular ribonucleoprotein complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004712 (protein serine/threonine/tyrosine kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042802 (identical protein binding)
GO:0043621 (protein self-association)
GO:0048156 (tau protein binding)
GO Biological Process GO:0000381 (regulation of alternative mRNA splicing, via spliceosome)
GO:0006468 (protein phosphorylation)
GO:0007623 (circadian rhythm)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0043518 (negative regulation of DNA damage response, signal transduction by p53 class mediator)
GO:0046777 (protein autophosphorylation)
GO:0048025 (negative regulation of mRNA splicing, via spliceosome)
GO:0090312 (positive regulation of protein deacetylation)

Target Cross References - Protein

canSAR Q63470
IntAct Q63470
Guide to Pharmacology 2009
Reactome R-RNO-1538133 (G0 and Early G1.)
UniProt Q63470

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR028318 (DYRK1A/MNB.)
Pfam PF00069 (Pkinase)
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