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Target Report Card

Target Name and Classification

Target ID CHEMBL5393
Preferred Name ATP-binding cassette sub-family G member 2
Synonyms ABCG2 | ABCP | ATP-binding cassette sub-family G member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CD_antigen=CD338 | CDw338 | MXR | Mitoxantrone resistance-associated protein | Placenta-specific ATP-binding cassette transporter | Urate exporter
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > primary active transporter > atp-binding cassette > abcg subfamily

Target Components

Component Description Relationship Accession
ATP-binding cassette sub-family G member 2 SINGLE PROTEIN Q9UNQ0

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000118777
Ensembl ENSG00000118777
GO Cellular Component GO:0005634 (nucleus)
GO:0005739 (mitochondrion)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0031966 (mitochondrial membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005215 (transporter activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008559 (xenobiotic-transporting ATPase activity)
GO:0015232 (heme transporter activity)
GO:0016887 (ATPase activity)
GO:0017127 (cholesterol transporter activity)
GO:0042626 (ATPase activity, coupled to transmembrane movement of substances)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0006855 (drug transmembrane transport)
GO:0006879 (cellular iron ion homeostasis)
GO:0015886 (heme transport)
GO:0033344 (cholesterol efflux)
GO:0042493 (response to drug)
GO:0042908 (xenobiotic transport)
GO:0046415 (urate metabolic process)
GO:0055085 (transmembrane transport)
Wikipedia ABCG2

Target Cross References - Protein

CGD Blood group, junior system
Human Protein Atlas ENSG00000118777
IntAct Q9UNQ0
Guide to Pharmacology 792
Open Targets ENSG00000118777
PharmGKB PA390
Reactome R-HSA-2161517 (Abacavir transmembrane transport.)
R-HSA-917937 (Iron uptake and transport.)
UniProt A0A1W3 A8K1T5 O95374 Q4W5I3 Q53ZQ1 Q569L4 Q5YLG4 Q86V64 Q8IX16 Q96LD6 Q96TA8 Q9BY73 Q9NUS0 Q9UNQ0

Target Cross References - Domain

InterPro IPR003439 (ABC_transporter-like.)
IPR003593 (AAA+_ATPase.)
IPR013525 (ABC_2_trans.)
IPR027417 (P-loop_NTPase.)
IPR030256 (ABCG2.)
Pfam PF00005 (ABC_tran)
PF01061 (ABC2_membrane)