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Target Report Card

Target Name and Classification

Target ID CHEMBL5335
Preferred Name Baculoviral IAP repeat-containing protein 3
Synonyms API2 | API2 | Apoptosis inhibitor 2 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | C-IAP2 | Cellular inhibitor of apoptosis 2 | IAP homolog C | Inhibitor of apoptosis protein 1 | MIHC | RING finger protein 49 | RING-type E3 ubiquitin transferase BIRC3 | RNF49 | TNFR2-TRAF-signaling complex protein 1 | hIAP-1 | hIAP1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Baculoviral IAP repeat-containing protein 3 SINGLE PROTEIN Q13489

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885522 Baculoviral IAP repeat-containing protein 3/Mucosa-associated lymphoid tissue lymphoma translocation protein 1 CHIMERIC PROTEIN

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000023445
Ensembl ENSG00000023445
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0032991 (macromolecular complex)
GO:0045121 (membrane raft)
GO Molecular Function GO:0004842 (ubiquitin-protein transferase activity)
GO:0005515 (protein binding)
GO:0016740 (transferase activity)
GO:0043027 (cysteine-type endopeptidase inhibitor activity involved in apoptotic process)
GO:0046872 (metal ion binding)
GO Biological Process GO:0002756 (MyD88-independent toll-like receptor signaling pathway)
GO:0006915 (apoptotic process)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007249 (I-kappaB kinase/NF-kappaB signaling)
GO:0007283 (spermatogenesis)
GO:0010803 (regulation of tumor necrosis factor-mediated signaling pathway)
GO:0016567 (protein ubiquitination)
GO:0016579 (protein deubiquitination)
GO:0031398 (positive regulation of protein ubiquitination)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0034121 (regulation of toll-like receptor signaling pathway)
GO:0035666 (TRIF-dependent toll-like receptor signaling pathway)
GO:0038061 (NIK/NF-kappaB signaling)
GO:0039535 (regulation of RIG-I signaling pathway)
GO:0042981 (regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0045088 (regulation of innate immune response)
GO:0050727 (regulation of inflammatory response)
GO:0051291 (protein heterooligomerization)
GO:0060544 (regulation of necroptotic process)
GO:0060546 (negative regulation of necroptotic process)
GO:0070424 (regulation of nucleotide-binding oligomerization domain containing signaling pathway)
GO:0090307 (mitotic spindle assembly)
GO:1990001 (inhibition of cysteine-type endopeptidase activity involved in apoptotic process)
GO:2000116 (regulation of cysteine-type endopeptidase activity)
Wikipedia Baculoviral_IAP_repeat-containing_protein_3

Target Cross References - Protein

canSAR Q13489
Human Protein Atlas ENSG00000023445
IntAct Q13489
Guide to Pharmacology 2792
Open Targets ENSG00000023445
PharmGKB PA25360
Reactome R-HSA-168638 (NOD1/2 Signaling Pathway.)
R-HSA-168927 (TICAM1, RIP1-mediated IKK complex recruitment.)
R-HSA-5213460 (RIPK1-mediated regulated necrosis.)
R-HSA-5357905 (Regulation of TNFR1 signaling.)
R-HSA-5357956 (TNFR1-induced NFkappaB signaling pathway.)
R-HSA-5668541 (TNFR2 non-canonical NF-kB pathway.)
R-HSA-5675482 (Regulation of necroptotic cell death.)
R-HSA-5676594 (TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.)
R-HSA-5689880 (Ub-specific processing proteases.)
R-HSA-937041 (IKK complex recruitment mediated by RIP1.)
UniProt Q13489 Q16628 Q9HC27 Q9UP46

Target Cross References - Domain

InterPro IPR001315 (CARD.)
IPR001370 (BIR_rpt.)
IPR001841 (Znf_RING.)
IPR011029 (DEATH-like_dom_sf.)
Pfam PF00619 (CARD)
PF00653 (BIR)

Target Cross References - Structure

PDBe 2UVL 3EB5 3EB6 3M0A 3M0D