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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5328
Target Type SINGLE PROTEIN
Preferred Name Thymidylate synthase
Synonyms TSase | Thymidylate synthase | thyA
Organism Lactobacillus casei
Species Group No
Protein Target Classification
  • enzyme > transferase

Target Components

Component Description Relationship Accession
Thymidylate synthase SINGLE PROTEIN P00469

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO Molecular Function GO:0004799 (thymidylate synthase activity)
GO:0008168 (methyltransferase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006231 (dTMP biosynthetic process)
GO:0006235 (dTTP biosynthetic process)
GO:0009165 (nucleotide biosynthetic process)
GO:0032259 (methylation)

Target Cross References - Protein

canSAR P00469
UniProt P00469

Target Cross References - Domain

InterPro IPR000398 (Thymidylate_synthase.)
IPR020940 (Thymidylate_synthase_AS.)
IPR023451 (Thymidate_synth/dCMP_Mease.)
IPR036926 (Thymidate_synth/dCMP_Mease_sf.)
Pfam PF00303 (Thymidylat_synt)

Target Cross References - Structure

PDBe 1BO7 1BO8 1BP0 1BP6 1BPJ 1JMF 1JMG 1JMH 1JMI 1LCA 1LCB 1LCE 1NJA 1NJB 1NJC 1NJD 1NJE 1TDA 1TDB 1TDC 1THY 1TSL 1TSM 1TSV More...
CREDO 1BO7 1BO8 1BP0 1BP6 1BPJ 1JMF 1JMG 1JMH 1JMI 1LCA 1LCB 1LCE 1NJA 1NJB 1NJC 1NJD 1NJE 1TDA 1TDB 1TDC 1THY 1TSL 1TSM 1TSV More...
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