ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL5261
Preferred Name Serine/threonine-protein kinase TAO1
Synonyms KIAA1361 | Kinase from chicken homolog B | MAP3K16 | MARK Kinase | MARKK | MARKK | PSK-2 | PSK2 | Prostate-derived STE20-like kinase 2 | Prostate-derived sterile 20-like kinase 2 | Serine/threonine-protein kinase TAO1 | TAOK1 | TAOK1 | Thousand and one amino acid protein kinase 1 | hKFC-B | hTAOK1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase tao subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase TAO1 SINGLE PROTEIN Q7L7X3

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000160551
Ensembl ENSG00000160551
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004709 (MAP kinase kinase kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0043539 (protein serine/threonine kinase activator activity)
GO Biological Process GO:0000186 (activation of MAPKK activity)
GO:0000187 (activation of MAPK activity)
GO:0006281 (DNA repair)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0007062 (sister chromatid cohesion)
GO:0007095 (mitotic G2 DNA damage checkpoint)
GO:0007257 (activation of JUN kinase activity)
GO:0007346 (regulation of mitotic cell cycle)
GO:0007399 (nervous system development)
GO:0016310 (phosphorylation)
GO:0032874 (positive regulation of stress-activated MAPK cascade)
GO:0032956 (regulation of actin cytoskeleton organization)
GO:0042981 (regulation of apoptotic process)
GO:0046330 (positive regulation of JNK cascade)
GO:0046777 (protein autophosphorylation)
GO:0051493 (regulation of cytoskeleton organization)
GO:0070507 (regulation of microtubule cytoskeleton organization)
GO:0097194 (execution phase of apoptosis)
Wikipedia TAOK1

Target Cross References - Protein

canSAR Q7L7X3
Human Protein Atlas ENSG00000160551
IntAct Q7L7X3
Guide to Pharmacology 2233
Open Targets ENSG00000160551
PharmGKB PA134872946
Pharos Q7L7X3 (Tbio)
Reactome R-HSA-141444 (Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.)
R-HSA-2467813 (Separation of Sister Chromatids.)
R-HSA-2500257 (Resolution of Sister Chromatid Cohesion.)
R-HSA-5663220 (RHO GTPases Activate Formins.)
R-HSA-68877 (Mitotic Prometaphase.)
UniProt A2RUT8 B7ZLV6 Q7L7X3 Q96L75 Q9H2K7 Q9H7S5 Q9P2I6

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)