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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5221
Target Type SINGLE PROTEIN
Preferred Name Nischarin
Synonyms I-1 | I1R | IR1 | Imidazoline receptor 1 | Imidazoline-1 receptor | Nisch | Nischarin
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Nischarin SINGLE PROTEIN Q4G017

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0055037 (recycling endosome)
GO Molecular Function GO:0005178 (integrin binding)
GO:0035091 (phosphatidylinositol binding)
GO:0042802 (identical protein binding)
GO Biological Process GO:0006006 (glucose metabolic process)
GO:0006915 (apoptotic process)
GO:0008217 (regulation of blood pressure)
GO:0016601 (Rac protein signal transduction)
GO:0030036 (actin cytoskeleton organization)
GO:0030336 (negative regulation of cell migration)
GO:0032228 (regulation of synaptic transmission, GABAergic)
GO:0048243 (norepinephrine secretion)

Target Cross References - Protein

canSAR Q4G017
IntAct Q4G017
UniProt Q4G017

Target Cross References - Domain

InterPro IPR001611 (Leu-rich_rpt.)
IPR001683 (Phox.)
IPR003591 (Leu-rich_rpt_typical-subtyp.)
IPR032675 (LRR_dom_sf.)
IPR036871 (PX_dom_sf.)
IPR037904 (Nischarin_PX.)
Pfam PF00787 (PX)
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