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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5192
Target Type SINGLE PROTEIN
Preferred Name Botulinum neurotoxin type A
Synonyms BOTOX | BoNT/A | Bontoxilysin-A | Botulinum neurotoxin A heavy chain | Botulinum neurotoxin A light chain | Botulinum neurotoxin type A | atx | bna | botA
Organism Clostridium botulinum
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mae clan > metallo protease m27 family

Target Components

Component Description Relationship Accession
Botulinum neurotoxin type A SINGLE PROTEIN P10845

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005576 (extracellular region)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0020002 (host cell plasma membrane)
GO:0030430 (host cell cytoplasm)
GO:0033644 (host cell membrane)
GO:0044156 (host cell junction)
GO:0044164 (host cell cytosol)
GO:0044221 (host cell synapse)
GO:0044231 (host cell presynaptic membrane)
GO Molecular Function GO:0004222 (metalloendopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0008320 (protein transmembrane transporter activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO:0050827 (toxin receptor binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0009405 (pathogenesis)
GO:0051609 (inhibition of neurotransmitter uptake)
GO:0071806 (protein transmembrane transport)

Target Cross References - Protein

canSAR P10845
IntAct P10845
Reactome R-HSA-5250968 (Toxicity of botulinum toxin type A (BoNT/A).)
UniProt P01561 P10845 P18639

Target Cross References - Domain

InterPro IPR000395 (Bot/tetX.)
IPR011065 (Kunitz_inhibitor_ST1-like.)
IPR012500 (Toxin_trans.)
IPR012928 (Toxin_rcpt-bd_N.)
IPR013104 (Toxin_rcpt-bd_C.)
IPR013320 (ConA-like_dom.)
Pfam PF01742 (Peptidase_M27)
PF07951 (Toxin_R_bind_C)
PF07952 (Toxin_trans)
PF07953 (Toxin_R_bind_N)

Target Cross References - Structure

PDBe 1XTF 1XTG 2ILP 2IMA 2IMB 2IMC 2ISE 2ISG 2ISH 2NYY 2NZ9 2VU9 2VUA 2W2D 3BOK 3BON 3BOO 3BTA 3BWI 3C88 3C89 3C8A 3C8B 3DDA More...
CREDO 1XTF 1XTG 2ILP 2IMA 2IMB 2IMC 2ISE 2ISG 2ISH 2NYY 2NZ9 2VU9 2VUA 2W2D 3BOK 3BON 3BOO 3BTA 3BWI 3C88 3C89 3C8A 3C8B 3DDA More...
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