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Target Report Card

Target Name and Classification

Target ID CHEMBL5162
Preferred Name Neuropeptide S receptor
Synonyms G-protein coupled receptor 154 | G-protein coupled receptor PGR14 | G-protein coupled receptor for asthma susceptibility | GPR154 | GPRA | NPSR1 | Neuropeptide S receptor | PGR14
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > neuropeptide receptor

Target Components

Component Description Relationship Accession
Neuropeptide S receptor SINGLE PROTEIN Q6W5P4

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000187258
Ensembl ENSG00000187258
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005000 (vasopressin receptor activity)
GO:0008188 (neuropeptide receptor activity)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007218 (neuropeptide signaling pathway)
GO:0051281 (positive regulation of release of sequestered calcium ion into cytosol)
Wikipedia Neuropeptide_S_receptor

Target Cross References - Protein

canSAR Q6W5P4
Human Protein Atlas ENSG00000187258
Guide to Pharmacology 302
Open Targets ENSG00000187258
PharmGKB PA134951416
Pharos Q6W5P4 (Tchem)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt A2RTZ4 Q2XP58 Q56H76 Q56H77 Q56H78 Q6JSL4 Q6JSL5 Q6JSL6 Q6JSL7 Q6JSL8 Q6W5P3 Q6W5P4 Q6ZMB8

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001817 (Vasoprsn_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
IPR027294 (NPS_rcpt.)
Pfam PF00001 (7tm_1)