ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL5131
Target Type SINGLE PROTEIN
Preferred Name Trypanothione reductase
Synonyms N(1),N(8)-bis(glutathionyl)spermidine reductase | TPR | Trypanothione reductase
Organism Trypanosoma cruzi
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Trypanothione reductase SINGLE PROTEIN P28593

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO Molecular Function GO:0009055 (electron carrier activity)
GO:0015036 (disulfide oxidoreductase activity)
GO:0015042 (trypanothione-disulfide reductase activity)
GO:0016491 (oxidoreductase activity)
GO:0016668 (oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor)
GO:0050660 (flavin adenine dinucleotide binding)
GO Biological Process GO:0022900 (electron transport chain)
GO:0045454 (cell redox homeostasis)
GO:0055114 (oxidation-reduction process)

Target Cross References - Protein

canSAR P28593
UniProt P28593

Target Cross References - Domain

InterPro IPR001100 (Pyr_nuc-diS_OxRdtase.)
IPR001864 (Trypnth_redctse.)
IPR004099 (Pyr_nucl-diS_OxRdtase_dimer.)
IPR012999 (Pyr_OxRdtase_I_AS.)
IPR016156 (FAD/NAD-linked_Rdtase_dimer_sf.)
IPR023753 (FAD/NAD-binding_dom.)
IPR036188 (FAD/NAD-bd_sf.)
Pfam PF02852 (Pyr_redox_dim)
PF07992 (Pyr_redox_2)

Target Cross References - Structure

PDBe 1AOG 1BZL 1GXF 1NDA
CREDO 1AOG 1BZL 1GXF 1NDA
spacer
spacer