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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5071
Target Type SINGLE PROTEIN
Preferred Name G protein-coupled receptor 44
Synonyms CD_antigen=CD294 | CRTH2 | Chemoattractant receptor-homologous molecule expressed on Th2 cells | DL1R | G-protein coupled receptor 44 | GPR44 | PTGDR2 | Prostaglandin D2 receptor 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > lipid-like ligand receptor (family a gpcr) > prostanoid receptor

Target Components

Component Description Relationship Accession
Prostaglandin D2 receptor 2 SINGLE PROTEIN Q9Y5Y4

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2386081 SETIPIPRANT G protein-coupled receptor 44 antagonist 3 Other PubMed
CHEMBL3137332 FEVIPIPRANT G protein-coupled receptor 44 antagonist 3 Other PubMed
CHEMBL560993 OC000459 G protein-coupled receptor 44 antagonist 2 PubMed
CHEMBL1742428 DONITRIPTAN G protein-coupled receptor 44 antagonist 2 Other Other
CHEMBL1914489 AZD1981 G protein-coupled receptor 44 antagonist 2 Other PubMed
CHEMBL1951575 VIDUPIPRANT G protein-coupled receptor 44 antagonist 2 PubMed
CHEMBL2442750 QAV680 G protein-coupled receptor 44 antagonist 2 PubMed
CHEMBL3545031 MK-1029 G protein-coupled receptor 44 antagonist 2 PubMed
CHEMBL3545109 ARRY-502 G protein-coupled receptor 44 antagonist 2 Other
CHEMBL3545343 ADC3680 G protein-coupled receptor 44 antagonist 2 Other Other PubMed
CHEMBL561132 MK-7246 G protein-coupled receptor 44 antagonist 1 PubMed PubMed
CHEMBL2181753 AM-211 G protein-coupled receptor 44 antagonist 1 Other
CHEMBL3544941 RG7185 G protein-coupled receptor 44 antagonist 1 Other
CHEMBL3545014 AM-461 G protein-coupled receptor 44 antagonist 1 Other
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000183134
Ensembl ENSG00000183134
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043005 (neuron projection)
GO Molecular Function GO:0001785 (prostaglandin J receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004956 (prostaglandin D receptor activity)
GO:0004958 (prostaglandin F receptor activity)
GO:0042923 (neuropeptide binding)
GO Biological Process GO:0006935 (chemotaxis)
GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0007218 (neuropeptide signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0019722 (calcium-mediated signaling)
GO:0045745 (positive regulation of G-protein coupled receptor protein signaling pathway)
GO:2000255 (negative regulation of male germ cell proliferation)
Wikipedia GPR44

Target Cross References - Protein

Human Protein Atlas ENSG00000183134
Guide to Pharmacology 339
Open Targets ENSG00000183134
PharmGKB PA28891
Pharos Q9Y5Y4 (Tchem)
Reactome R-HSA-391908 (Prostanoid ligand receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt O94765 Q4QRI6 Q9Y5Y4

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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