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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5043
Preferred Name Endoplasmic reticulum aminopeptidase 2
Synonyms ERAP2 | Endoplasmic reticulum aminopeptidase 2 | L-RAP | LRAP | Leukocyte-derived arginine aminopeptidase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mae clan > metallo protease m1 family

Target Components

Component Description Relationship Accession
Endoplasmic reticulum aminopeptidase 2 SINGLE PROTEIN Q6P179

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3831223 Aminopeptidase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164308
Ensembl ENSG00000164308
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004177 (aminopeptidase activity)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0042277 (peptide binding)
GO:0046872 (metal ion binding)
GO:0070006 (metalloaminopeptidase activity)
GO Biological Process GO:0002250 (adaptive immune response)
GO:0002376 (immune system process)
GO:0002474 (antigen processing and presentation of peptide antigen via MHC class I)
GO:0006508 (proteolysis)
GO:0007165 (signal transduction)
GO:0007267 (cell-cell signaling)
GO:0008217 (regulation of blood pressure)
GO:0019885 (antigen processing and presentation of endogenous peptide antigen via MHC class I)
GO:0043171 (peptide catabolic process)

Target Cross References - Protein

canSAR Q6P179
Human Protein Atlas ENSG00000164308
IntAct Q6P179
Guide to Pharmacology 1567
Open Targets ENSG00000164308
PharmGKB PA162385208
Reactome R-HSA-983170 (Antigen Presentation: Folding, assembly and peptide loading of class I MHC.)
UniProt Q6P179 Q7Z5K1 Q8TD32 Q8WVJ4 Q9HBX2

Target Cross References - Domain

InterPro IPR001930 (Peptidase_M1.)
IPR014782 (Peptidase_M1_N.)
IPR024571 (ERAP1-like_C_dom.)
IPR033528 (ERAP2.)
IPR034016 (M1_APN-typ.)
Pfam PF01433 (Peptidase_M1)
PF11838 (ERAP1_C)

Target Cross References - Structure

PDBe 3SE6 4E36 4JBS 5AB0 5AB2 5CU5 5J6S 5K1V
CREDO 3SE6 4E36 4JBS 5AB0 5AB2 5CU5 5J6S 5K1V