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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5035
Target Type SINGLE PROTEIN
Preferred Name Heme oxygenase 1
Synonyms HO-1 | HSP32 | Heme oxygenase 1 | Hmox1
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Heme oxygenase 1 SINGLE PROTEIN P06762

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005730 (nucleolus)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005901 (caveola)
GO:0016020 (membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0004392 (heme oxygenase (decyclizing) activity)
GO:0004630 (phospholipase D activity)
GO:0005515 (protein binding)
GO:0016491 (oxidoreductase activity)
GO:0019899 (enzyme binding)
GO:0020037 (heme binding)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001666 (response to hypoxia)
GO:0002246 (wound healing involved in inflammatory response)
GO:0006644 (phospholipid metabolic process)
GO:0006788 (heme oxidation)
GO:0006879 (cellular iron ion homeostasis)
GO:0006915 (apoptotic process)
GO:0006979 (response to oxidative stress)
GO:0007264 (small GTPase mediated signal transduction)
GO:0008217 (regulation of blood pressure)
GO:0008219 (cell death)
GO:0008285 (negative regulation of cell proliferation)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0010656 (negative regulation of muscle cell apoptotic process)
GO:0016239 (positive regulation of macroautophagy)
GO:0016242 (negative regulation of macroautophagy)
GO:0031670 (cellular response to nutrient)
GO:0032764 (negative regulation of mast cell cytokine production)
GO:0034101 (erythrocyte homeostasis)
GO:0034395 (regulation of transcription from RNA polymerase II promoter in response to iron)
GO:0034605 (cellular response to heat)
GO:0035094 (response to nicotine)
GO:0035556 (intracellular signal transduction)
GO:0042167 (heme catabolic process)
GO:0042168 (heme metabolic process)
GO:0042542 (response to hydrogen peroxide)
GO:0043065 (positive regulation of apoptotic process)
GO:0043305 (negative regulation of mast cell degranulation)
GO:0043392 (negative regulation of DNA binding)
GO:0043433 (negative regulation of sequence-specific DNA binding transcription factor activity)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0043619 (regulation of transcription from RNA polymerase II promoter in response to oxidative stress)
GO:0043627 (response to estrogen)
GO:0045766 (positive regulation of angiogenesis)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0048662 (negative regulation of smooth muscle cell proliferation)
GO:0051090 (regulation of sequence-specific DNA binding transcription factor activity)
GO:0051260 (protein homooligomerization)
GO:0055072 (iron ion homeostasis)
GO:0055114 (oxidation-reduction process)
GO:0071243 (cellular response to arsenic-containing substance)
GO:0071276 (cellular response to cadmium ion)
GO:0071456 (cellular response to hypoxia)
GO:0072719 (cellular response to cisplatin)
GO:0090050 (positive regulation of cell migration involved in sprouting angiogenesis)
GO:0097421 (liver regeneration)
GO:1902042 (negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)
GO:1903589 (positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)
GO:1904036 (negative regulation of epithelial cell apoptotic process)
GO:1904706 (negative regulation of vascular smooth muscle cell proliferation)

Target Cross References - Protein

canSAR P06762
Guide to Pharmacology 1441
Reactome R-RNO-189483 (Heme degradation.)
R-RNO-917937 (Iron uptake and transport.)
UniProt P06762 Q5BK87

Target Cross References - Domain

InterPro IPR002051 (Haem_Oase.)
IPR016053 (Haem_Oase-like.)
IPR016084 (Haem_Oase-like_multi-hlx.)
IPR018207 (Haem_oxygenase_CS.)
Pfam PF01126 (Heme_oxygenase)

Target Cross References - Structure

PDBe 1DVE 1DVG 1IRM 1IVJ 1IX3 1IX4 1J02 1J2C 1UBB 1ULX 1VGI 2DY5 2E7E 2ZVU 3I9T 3I9U 3WKT 4G7L 4G7P 4G7T 4G7U 4G8P 4G8U 4G8W More...
CREDO 1DVE 1DVG 1IRM 1IVJ 1IX3 1IX4 1J02 1J2C 1UBB 1ULX 1VGI 2DY5 2E7E 2ZVU 3I9T 3I9U 3WKT 4G7L 4G7P 4G7T 4G7U 4G8P 4G8U 4G8W More...
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